Nitric oxide and chronic HCV and HIV infections

Digestive Diseases and Sciences
Gerond Lake-BakaarVito Mazzoccoli

Abstract

High concentrations of nitric oxide (NO) are generated by the inducible form of the enzyme nitric oxide synthase (iNOS), which is expressed in activated macrophages and in hepatocytes. Increased expression of iNOS in hepatocytes or macrophages might be expected in chronic HCV liver disease and HIV infections. This might in turn be reflected in increased serum NO levels in these two conditions. In view of the discrepant findings in published reports, we measured serum NO levels in a large number of chronic HCV-infected patients and patients with chronic HIV infections with or without AIDS-related opportunistic infection. We also localized HCV and iNOS antigens by immunohistochemistry, in liver biopsy tissue from patients with chronic HCV-related hepatitis, HCV-related cirrhosis, and HCV-related hepatocellular carcinoma. A group of 121 subjects with serological evidence of HCV with or without HIV infection were studied. These were compared with 14 controls without HIV or HCV disease (group A). Among the subjects with HCV, 35 were negative for HIV (group B), 66 were HIV positive (group C), and 20 had AIDS-related opportunistic infection (group D). The serum NO concentration was determined by the Brucine method. A well-characterize...Continue Reading

Citations

Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kerstin KoerberGisa Tiegs
Nov 20, 2014·The Journal of Biological Chemistry·Ashima BhaskarAmit Singh
Apr 27, 2002·Annals of the New York Academy of Sciences·Barry Drew, Christiaan Leeuwenburgh

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