Nitric oxide and endothelium-derived hyperpolarizing factor: formation and interactions

Prostaglandins, Leukotrienes, and Essential Fatty Acids
J BauersachsR Busse

Abstract

Nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) represent the two major endothelial autacoids involved in the local control of vascular tone. Here we describe a novel pathway leading to the calcium-independent activation of the endothelial NO synthase by shear stress and enhanced cellular tyrosine phosphorylation. In addition we present evidence that NO inhibits the formation of EDHF, which we have characterized as a transferable, beta-naphthoflavone-inducible P450-dependent metabolite of arachidonic acid.

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Citations

Aug 23, 2001·Pharmacology & Therapeutics·P A CahillJ V Sitzmann
Jun 20, 2001·Trends in Cardiovascular Medicine·M MedhoraD Harder
Feb 26, 2008·British Journal of Pharmacology·D SodiniF Coceani
Dec 6, 2007·Journal of Clinical Gastroenterology·Reiner Wiest
Feb 1, 2009·The Indian Journal of Surgery·Ashish GuptaSoumya Gupta
Feb 25, 2009·International Journal of Colorectal Disease·Chun-Chi LinTzu-Chen Lin
Apr 4, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Satyan LakshminrusimhaFrederick C Morin
May 23, 2002·BMC Cardiovascular Disorders·Rikard AlmMalin Malmsjö
Sep 3, 2014·Physiology·David C Hill-EubanksMark T Nelson
Jan 3, 2001·Medicinal Research Reviews·C E HillS L Sandow
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Y WuG Kaley
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A HuangG Kaley
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J P HalcoxA A Quyyumi

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