Nitric Oxide and Hydrogen Sulfide: A Nice Pair in the Respiratory System

Current Medicinal Chemistry
Salvatore FuschilloMauro Maniscalco

Abstract

Nitric Oxide (NO) is internationally regarded as a signal molecule involved in several functions in the respiratory tract under physiological and pathogenic conditions. Hydrogen Sulfide (H2S) has also recently been recognized as a new gasotransmitter with a diverse range of functions similar to those of NO. Depending on their respective concentrations, both these molecules act synergistically or antagonistically as signals or damage promoters. Nevertheless, available evidence shows that the complex biological connections between NO and H2S involve multiple pathways and depend on the site of action in the respiratory tract, as well as on experimental conditions. This review will provide an update on these two gasotransmitters in physiological and pathological processes.

References

Jan 14, 1992·European Journal of Pharmacology·M G BelvisiP J Barnes
Feb 11, 1992·European Journal of Pharmacology·A IalentiM Di Rosa
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·R H BrownC A Hirshman
Nov 16, 1993·European Journal of Pharmacology·M G PerssonL E Gustafsson
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·R M KacmarekD C Johnson
Mar 1, 1996·Immunology Today·K RackeI Wessler
Aug 28, 1997·Biochemical and Biophysical Research Communications·R HosokiH Kimura
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J N WilcoxP A Marsden
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·M SchuilingJ Zaagsma
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·K Y XuL C Becker
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Sadeghi-HashjinF P Nijkamp
Oct 27, 2001·Acta Physiologica Scandinavica·F S LarouxM B Grisham
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J K ChoateD J Paterson
Jan 30, 2003·Thorax·F L M Ricciardolo
Jun 7, 2005·British Journal of Pharmacology·Marcello TrevisaniSelena Harrison
Nov 24, 2005·Chest·Ya-Hong ChenChao-Shu Tang
Mar 17, 2006·Biochemical and Biophysical Research Communications·Matthew WhitemanPhilip K Moore
Apr 14, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M ManiscalcoG Pelaia
Jun 15, 2007·Immunology Letters·György NagyAndrew P Cope
Aug 25, 2007·American Journal of Respiratory and Critical Care Medicine·Dave SinghBrian J O'Connor
Apr 22, 2008·Methods in Enzymology·Jon M FukutoNazareno Paolocci
Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Qian Chen YongJin-Song Bian
Jan 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mozow YusofRonald J Korthuis
Sep 23, 2009·Antioxidants & Redox Signaling·John W CalvertDavid J Lefer
Jul 28, 2010·Cardiovascular Research·Qian-Chen YongJin-Song Bian
Nov 4, 2010·Molecular Medicine·Jochen Grommes, Oliver Soehnlein
Nov 6, 2010·Antioxidants & Redox Signaling·Ruth PietriJuan López-Garriga
Dec 15, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Amit K YadavSadis Matalon
Feb 8, 2011·American Journal of Respiratory Cell and Molecular Biology·Mark M PerryKian Fan Chung

❮ Previous
Next ❯

Citations

Jun 10, 2020·American Journal of Physiology. Cell Physiology·Guangdong Yang
Dec 22, 2020·Current Medicinal Chemistry·Mauro Maniscalco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Experimental Botany
Francisco J CorpasJosé M Palma
American Journal of Physiology. Lung Cellular and Molecular Physiology
Shuai YuanChristopher G Kevil
© 2021 Meta ULC. All rights reserved