Nitric oxide and liver microcirculation during autoregulation and haemorrhagic shock in rabbit model

British Journal of Anaesthesia
F LhuillierJ-P Viale

Abstract

Direct evidence of nitric oxide (NO) involvement in the regulation of hepatic microcirculation is not yet available under physiological conditions nor in haemorrhagic shock. A laser Doppler flowmetry was used to measure liver perfusion index and a specific NO-sensitive electrode was inserted into liver parenchyma of anaesthetized rabbits. Hepatic autoregulation during moderate hypovolaemia {mean arterial pressure at 50 mm Hg without liver perfusion alteration; blood withdrawal 17.7 (4.2) ml [mean (SD)]} or haemorrhagic shock [mean arterial pressure at 20 mm Hg associated with liver perfusion impairment and lactic acidosis; blood withdrawal 56.0 (6.8) ml] were investigated over 60 min and were followed by a rapid infusion of the shed blood. Involvement of NO synthases was evaluated using a non-specific inhibitor, NAPNA (Nomega-nitro-L-arginine P-nitro-anilide). In the autoregulation group, a decrease [30.0 (4.0) mm Hg] of mean arterial pressure did not alter liver perfusion index, whereas the liver NO concentration increased and reached a plateau [125 (10)%; compared with baseline; P<0.05]. This NO concentration was reduced to zero by the administration of NO synthase inhibitor. Haemorrhagic shock led to a rapid decrease in live...Continue Reading

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Citations

Aug 31, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Hamzeh Amiri
May 21, 2013·Journal of the Chinese Medical Association : JCMA·Chiung-Yu ChenShu-Chu Shiesh
Mar 13, 2012·Sleep Medicine Reviews·Raymond CespuglioSabine Gautier-Sauvigné
Dec 5, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Florian LoeheMartin Kurt Angele
Dec 21, 2011·The Journal of Trauma·Jacek SzopinskiMaria Semionow

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