Nitric oxide and oral cancer: a review

Oral Oncology
Sheetal Korde ChoudhariV Poornima

Abstract

Nitric oxide (NO), a short-lived, endogenously produced gas, plays key role in various physiological as well as pathological processes. NO-inducing cell signaling events within the cell producing it and the diffusibility of it in other cells have led to the discovery of various physiological functions of NO including vasodilation, respiration, cell migration, immune response and apoptosis. On the other hand, excessive and unregulated NO synthesis has been implicated in many pathophysiological conditions including cancer. Research on NO, during the past few years is one of the growing areas in cancer biology. The high incidence of oral cancer and precancer has been linked with habits of tobacco chewing and smoking and NO has been said as the "messenger of death" in tobacco related diseases. NO seems to play a part in various stages of carcinogenesis from initiation to progression. However, there is considerable controversy and confusion in understanding its role in cancer biology. It is said to have both, tumoricidal as well as tumor promoting effects and these depend on its timing, location and concentration. Further, NO has also been shown to have antitumor, chemopreventive and therapeutic abilities. Here is an overview in whi...Continue Reading

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Citations

Oct 16, 2013·Oral Oncology·Sheetal Korde ChoudhariSatyajit Tekade
May 31, 2013·World Journal of Surgical Oncology·Sheetal Korde ChoudhariVaishali Joshi
Apr 2, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·R MetgudK Singh
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Mar 10, 2015·Journal of Breath Research·Wolfgang Schroeder
Feb 14, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sahar AoufHedi Harizi
Aug 8, 2019·MSystems·Philip StashenkoJorge Frias-Lopez
Oct 21, 2015·Medical Science Monitor Basic Research·Sergey KalishIgor Malyshev
Aug 28, 2013·Molecular Cancer Therapeutics·Hau-Lun HuangMing-Derg Lai

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