PMID: 8594876Dec 1, 1995Paper

Nitric oxide and prostaglandins are involved in the macula densa control of the renin system

The American Journal of Physiology
K SchrickerA Kurtz

Abstract

This study sought to examine the involvement of prostaglandins and of nitric oxide (NO) in the macula densa-dependent activation of the renin system in vivo. For this purpose, male Sprague-Dawley rats were chronically infused with furosemide (12 mg/day) for 6 days to inhibit macula densa salt transport. To inhibit the synthesis of prostaglandins and of NO, animals were injected with indomethacin (2 mg/kg twice daily) and with nitro-L-arginine methyl ester (L-NAME; 40 mg/kg twice daily) for the last 2 days of the experiment, respectively. Furosemide infusion increased plasma renin activity (PRA) from 8.8 +/- 1.4 to 41 +/- 5.2 ng angiotensin I (ANG I).h-1.ml-1 and renin mRNA levels from 112 +/- 8 of standard to 249 +/- 18% of standard. After treatment with indomethacin, the furosemide-induced increases in renin mRNA levels was attenuated to 190 +/- 11% of standard. After injections of L-NAME, both the furosemide-induced increases of renin mRNA levels and of PRA were reduced to 126 +/- 14% of standard and 22 +/- 5 ng ANG I.h-1.ml-1, respectively. These findings suggest that activation of renin gene expression by blockade of the macula densa function is dependent on intact NO and prostaglandin formation, whereas for stimulation of ...Continue Reading

Citations

Jul 15, 2000·American Journal of Physiology. Renal Physiology·H F ChengR C Harris
Mar 16, 2001·American Journal of Physiology. Renal Physiology·W WeichertS Bachmann
Aug 19, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Helle C ThiessonOle Skøtt
Feb 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elzbieta Kompanowska-JezierskaPeter Bie
Nov 30, 2000·American Journal of Physiology. Renal Physiology·D AndreasenO Skøtt
May 18, 2006·American Journal of Physiology. Renal Physiology·Tianxin YangJurgen B Schnermann
Oct 13, 2010·Annual Review of Physiology·Armin Kurtz
Jun 6, 2012·Pflügers Archiv : European journal of physiology·Jurgen Schnermann, Josephine P Briggs
Jun 16, 2001·American Journal of Physiology. Renal Physiology·R C Harris, M D Breyer
Feb 8, 2002·American Journal of Physiology. Renal Physiology·K HöcherlA Kurtz
Jan 3, 2001·American Journal of Physiology. Renal Physiology·B MannA Kurtz
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hui-Fang ChengRaymond C Harris
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Apr 17, 2010·Journal of the American Society of Nephrology : JASN·Limeng ChenJosephine P Briggs
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Hayo CastropJurgen Schnermann

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