Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia

International Journal of Molecular Sciences
Keiichi MatsubaraAkihiro Nawa

Abstract

Preeclampsia (PE) is characterized by disturbed extravillous trophoblast migration toward uterine spiral arteries leading to increased uteroplacental vascular resistance and by vascular dysfunction resulting in reduced systemic vasodilatory properties. Its pathogenesis is mediated by an altered bioavailability of nitric oxide (NO) and tissue damage caused by increased levels of reactive oxygen species (ROS). Furthermore, superoxide (O2-) rapidly inactivates NO and forms peroxynitrite (ONOO-). It is known that ONOO- accumulates in the placental tissues and injures the placental function in PE. In addition, ROS could stimulate platelet adhesion and aggregation leading to intravascular coagulopathy. ROS-induced coagulopathy causes placental infarction and impairs the uteroplacental blood flow in PE. The disorders could lead to the reduction of oxygen and nutrients required for normal fetal development resulting in fetal growth restriction. On the other hand, several antioxidants scavenge ROS and protect tissues against oxidative damage. Placental antioxidants including catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) protect the vasculature from ROS and maintain the vascular function. However, placental ische...Continue Reading

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·W P ArnoldF Murad
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Aug 1, 1989·British Journal of Obstetrics and Gynaecology·I A GreerA A Calder
Mar 1, 1994·The Biochemical Journal·R G Knowles, S Moncada
Sep 25, 1995·Biochemical and Biophysical Research Communications·T HayashiA Iguchi
Oct 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·T W GauthierA M Lefer
Feb 1, 1997·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K HarringtonS Campbell
May 1, 1997·Disease-a-month : DM·R G KilbournC Szabó
Aug 1, 1997·General Pharmacology·C Thiemermann
Jul 31, 1998·Cardiovascular Research·P CannonR E Michler
Aug 6, 1998·Gynecologic and Obstetric Investigation·U Mutlu-TürkogluM Uysal
Mar 17, 1999·American Journal of Obstetrics and Gynecology·A C StaffT Henriksen
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·C A Hubel
Jan 7, 2000·The American Journal of Pathology·A ManyY Zhou
Feb 24, 2000·The Journal of Pathology·H Li, U Förstermann
Feb 26, 2000·Acta Physiologica Scandinavica·R M CareyH M Siragy
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·E A KirkR C LeBoeuf
Nov 10, 2000·Biochemical and Biophysical Research Communications·V Ullrich, M Bachschmid
Dec 20, 2000·The Journal of Experimental Medicine·B van der LooT F Lüscher
Jul 13, 2001·The American Journal of Cardiology·P PatetsiosT F Panetta
Jul 21, 2001·Circulation Research·P T NowickiN A Flavahan
Jan 11, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R MadazliN Tolun
Feb 6, 2003·Journal of Hypertension·Virginia M LeeLeong L Ng
Mar 22, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Emiko AbeKenji Kameda
May 20, 2003·Experimental & Molecular Medicine·Jing Hyang SongIll Min Chung

❮ Previous
Next ❯

Citations

Oct 8, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sebastian KwiatkowskiBarbara Dolegowska
Sep 8, 2015·Archives of Toxicology·Marian ValkoKamil Musílek
Dec 8, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Shu-Zhi WangZheng-Hong Qin
Jan 13, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jie ChenZhice Xu
Dec 28, 2016·Placenta·Olivia HollandAnthony V Perkins
Apr 10, 2017·Immunologic Research·Luiza Oliveira PerucciLirlândia Pires Sousa
Mar 23, 2017·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·K MadurayT Naicker
Feb 23, 2018·Journal of Molecular Endocrinology·Jonathan PhamMana M Parast
Aug 19, 2015·Hypertension·Andreas BrückmannDietmar Schlembach
Mar 9, 2019·International Journal of Molecular Sciences·Manon BosMarie-Louise P van der Hoorn
Apr 11, 2019·Journal of Developmental Origins of Health and Disease·W Tong, D A Giussani
Feb 28, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Venkata Ramana VakaBabbette LaMarca
Oct 17, 2018·Mini Reviews in Medicinal Chemistry·Seyithan TaysiMustafa Demir
May 2, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jinjin LiPhilip N Baker
May 19, 2018·International Journal of Molecular Sciences·Rajaa AouacheFrancisco Miralles
Aug 21, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Denise C CorneliusBabbette LaMarca
Jul 11, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Şerif Aksin, Cengiz Andan
Mar 8, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mayara Caldeira-DiasValéria C Sandrim
Jan 20, 2020·Prenatal Diagnosis·Lola LoussertPaul Guerby
Aug 12, 2017·Clinical Science·Rachel J SkowMargie H Davenport
Oct 1, 2017·BMC Pregnancy and Childbirth·Ying ZhangYuanyuan Wu
Aug 22, 2018·Reproductive Biology and Endocrinology : RB&E·Jiayin LuYulan Dong
Jan 11, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuanyuan LiuHongjun Shi
Jul 7, 2019·International Journal of Molecular Sciences·Shu-Wing NgErrol R Norwitz
Aug 21, 2019·Journal of the American Heart Association·Tiange LiuNoel T Mueller
Oct 22, 2020·Mediators of Inflammation·Michał MichalczykRafał Rzepka
Jan 1, 2021·The Journal of Clinical Endocrinology and Metabolism·Chia-Chi LiuAnnemarie Hennessy
Jan 8, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Aditi A GodhamgaonkarSadhana R Joshi
Jan 21, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nitalia NaidooThajasvarie Naicker
Jan 15, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xuan ChenJinghong Rao
Feb 8, 2021·Reproductive Biology and Endocrinology : RB&E·Marwa AtallahKoji Abe
Nov 17, 2020·American Journal of Physiology. Renal Physiology·Evangeline DeerBabbette LaMarca
Jan 17, 2021·American Journal of Obstetrics & Gynecology MFM·Evangeline DeerBabbette LaMarca
Nov 27, 2020·Frontiers in Physiology·Teresa TropeaElizabeth C Cottrell

❮ Previous
Next ❯

Methods Mentioned

BETA
PMA

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

The Journal of Obstetrics and Gynaecology Research
Keiichi MatsubaraMasaharu Ito
Gynecologic and Obstetric Investigation
A ChuiJ M Said
Nihon rinsho. Japanese journal of clinical medicine
Yukihito Higashi, Masao Yoshizumi
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
J B SharmaS Mittal
© 2022 Meta ULC. All rights reserved