PMID: 18404792Apr 12, 2008Paper

Nitric oxide and the collagenous protein biosynthesis of irradiated chick chorioallantoic membrane

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
Christos Hadjimichael, D Kardamakis

Abstract

To study the effect of irradiation doses (2 Gy and 5 Gy) on the rate of collagenous protein biosynthesis (CPB) of chick embryo chorioallantoic membrane (CAM) and to investigate the possible role of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME), its inactive enantiomer D-NAME and the NO donor sodium nitroprusside (SNP) in this effect. The originally established CAM angiogenesis model was used with few modifications described earlier. The CAM areas were irradiated on the 10th or the 14th day of embryo development with a single dose of 2 or 5 Gy and the CPB was determined 6 h later. L-NAME, D-NAME and SNP were added to the CAM after the irradiation. The experiments didn't show any significant differences in almost all of the treatment courses. In the 10-day CAM preparations the irradiation not significantly (NS) inhibited the CAM CPB, whereas L-NAME abolished this effect only in the case of 2 Gy dose (NS). The addition of SNP or D-NAME in the post-irradiated 10-day CAM exerted radiosensitization that was significant only in the case of the combination of D-NAME with the 5 Gy dose. There was no significant effect on the respective treatments of the 14-day CAM. The CPB of the 14-day CAM was sig...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Pharmacology
E Pipili-SynetosM E Maragoudakis
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Hui WangLian Duan
Anticancer Research
Christos PolytarchouEvangelia Papadimitriou
© 2022 Meta ULC. All rights reserved