Nitric oxide and the depressor response to angiotensin blockade in hypertension

Hypertension
H GuanA Nasjletti

Abstract

We investigated the contribution of nitric oxide to the short-term blood pressure reduction caused by interruption of the renin-angiotensin system in angiotensin-dependent hypertension. The blood pressure of rats made hypertensive by coarctation of the aorta between the renal arteries at their origin fell after administration of the angiotensin-converting enzyme inhibitor ramiprilat (2 mg/kg IV; -75 +/- 5 mm Hg) or the angiotensin II antagonist losartan (30 mg/kg IV; -79 +/- 6 mm Hg). But the antihypertensive effect of these agents was attenuated in rats pretreated with NG-nitro-L-arginine methyl ester (10 mg/kg IV) to inhibit nitric oxide synthesis (ramiprilat, -23 +/- 7 mm Hg; losartan, -37 +/- 5 mm Hg). In rats made hypertensive by long-term infusion of angiotensin II (60 ng/min IV, 6 to 7 days), the vasodepressor response to discontinuation of the angiotensin II infusion also was attenuated by pretreatment with the nitric oxide synthesis inhibitor (-52 +/- 7 versus -31 +/- 7 mm Hg); this attenuation was not demonstrable in rats receiving sodium nitroprusside (1 microgram.kg-1.min-1 IV) to replace the loss of endogenous nitric oxide (-72 +/- 9 mm Hg). Pretreatment with NG-nitro-L-arginine methyl ester did not interfere with ...Continue Reading

References

Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
May 10, 1988·European Journal of Pharmacology·M J VidalP M Vanhoutte

❮ Previous
Next ❯

Citations

Mar 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Santhanam A V Raghavan, Madhu Dikshit
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Christiane PeesPeter Gohlke
Aug 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Peter M AbadirJeremy D Walston
Feb 4, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Peter M AbadirHelmy M Siragy
Oct 22, 1998·Journal of Cardiovascular Pharmacology·E TurkstraH A Koomans
Aug 1, 1996·Clinical and Experimental Pharmacology & Physiology·P M Vanhoutte
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ShahR J Groszmann
Nov 26, 2010·Clinics in Geriatric Medicine·Peter M Abadir
Feb 21, 2006·Journal of Pharmacological and Toxicological Methods·Dhvanit I ShahSunita S Goswami
Oct 13, 2005·Kidney & Blood Pressure Research·Mahmoud M KhattabOthman Al-Shabanah
Mar 10, 2006·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Adriaan A VoorsWiek H van Gilst
Jun 16, 2001·American Journal of Physiology. Renal Physiology·Y QuirozB Rodríguez-Iturbe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Aortic Coarctation

Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.