Nitric oxide and thyroid hormone receptor alpha 1 contribute to ovarian follicular development in immature hyper- and hypo-thyroid rats

Reproductive Biology
Kaizhi ZhengFangxiong Shi

Abstract

Thyroid dysfunction can cause ovarian cycle and ovulatory disturbances, however, the molecular link(s) between these two disorders remains largely unknown. In the current study, we examined the roles of nitric oxide synthase (NOS) and thyroid hormone receptor alpha 1 (TRα1) in these disorders using immature hyper-thyroid (hyper-T) and hypo-thyroid (hypo-T) rats. In comparison to controls, hyper-T rats had higher serum concentrations of triiodothyronine (T3) and thyroxine (T4), whereas hypo-T rats had lower serum T3 and T4. Serum estradiol (E2) level was decreased in both hyper-T and hypo-T animals and serum E2 in hyper-T rats were lower than in hypo-T rats. We found that neuronal NOS (nNOS) and TRα1 were present in oocytes, granulosa cells and theca cells of all examined rat groups. Ovarian nitric oxide (NO) content and the constitutive NOS (cNOS) activity in hyper-T rats were significantly decreased compared with control or hypo-T rats. Moreover, the number of large antral follicles was reduced in hyper-T rats, and number of primordial follicles was decreased in hypo-T rats compared with control rats. In conclusion, we observed an association between thyroid hormone and NO signaling pathways during the process of ovarian folli...Continue Reading

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Citations

Feb 24, 2016·Indian Journal of Endocrinology and Metabolism·Sanjay SaranPankaj Agrawal
Mar 24, 2015·The Journal of Reproduction and Development·Lingfa KongGen Watanabe
Jun 9, 2016·Endocrine Research·Julia Rodríguez-CastelánEstela Cuevas-Romero
Oct 21, 2016·Cell and Tissue Research·Yu DingCheng Zhang
May 17, 2018·Biology of Reproduction·Juneo F SilvaRogéria Serakides
Aug 30, 2019·Cell and Tissue Research·Kaili XuCheng Zhang
Jun 5, 2020·Journal of Clinical Medicine·Marco ColellaConcetta Ambrosino
Dec 8, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Quanwei WeiFangxiong Shi
Jun 24, 2018·Journal of Endocrinological Investigation·R CanipariC Verga Falzacappa
Apr 12, 2019·Reproduction in Domestic Animals = Zuchthygiene·Dan SongFangxiong Shi
Dec 14, 2018·Current Opinion in Endocrine and Metabolic Research·Arturo Hernandez

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