Nitric oxide as a messenger between neurons and satellite glial cells in dorsal root ganglia

Glia
Vitali Belzer, Menachem Hanani

Abstract

Abnormal neuronal activity in sensory ganglia contributes to chronic pain. There is evidence that signals can spread between cells in these ganglia, which may contribute to this activity. Satellite glial cells (SGCs) in sensory ganglia undergo activation following peripheral injury and participate in cellular communication via gap junctions and chemical signaling. Nitric oxide (NO) is released from neurons in dorsal root ganglia (DRG) and induces cyclic GMP (cGMP) production in SCGs, but its role in SGC activation and neuronal excitability has not been explored. It was previously reported that induction of intestinal inflammation with dinitrobenzoate sulfonate (DNBS) increased gap junctional communications among SGCs, which contributed to neuronal excitability and pain. Here we show that DNBS induced SGC activation in mouse DRG, as assayed by glial fibrillary acidic protein upregulation. DNBS also upregulated cGMP level in SGCs, consistent with NO production. In vitro studies on intact ganglia from DNBS-treated mice showed that blocking NO synthesis inhibited both SGCs activation and cGMP upregulation, indicating an ongoing NO production. Application of NO donor in vitro induced SGC activation, augmented gap junctional communic...Continue Reading

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Citations

Jun 26, 2020·Physiological Reviews·Nanna Brix FinnerupTroels Staehelin Jensen
Aug 28, 2020·Journal of Dental Research·H LiangH Long
Jul 24, 2020·Nature Reviews. Neuroscience·Menachem Hanani, David C Spray
Oct 18, 2020·International Journal of Molecular Sciences·Pamela PignatelliMaria Cristina Curia
Jan 4, 2021·Stem Cell Reviews and Reports·Dongyan WangHuanxiang Zhang
Sep 9, 2019·Autonomic Neuroscience : Basic & Clinical·Rachel Feldman-Goriachnik, Menachem Hanani
Feb 2, 2021·Neurochemical Research·Menachem Hanani, Alexei Verkhratsky
Feb 26, 2021·Brain Research·Rachel Feldman-Goriachnik, Menachem Hanani
May 4, 2021·British Journal of Pharmacology·Hannes SchmidtAchim Schmidtko
Aug 28, 2021·Biomedicines·Kjeld Morten MohrChristian Bjerggaard Vaegter
Sep 18, 2021·Journal of Neuroinflammation·Becky J ProskocilMatthew G Drake
Dec 9, 2021·Journal of Cellular and Molecular Medicine·Bei HuangEva Leitzen

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