Nitric oxide as a regulator of behavior: new ideas from Aplysia feeding

Progress in Neurobiology
Abraham J Susswein, Hillel J Chiel

Abstract

Nitric oxide (NO) regulates Aplysia feeding by novel mechanisms, suggesting new roles for NO in controlling the behavior of higher animals. In Aplysia, (1) NO helps maintain arousal when produced by neurons responding to attempts to swallow food; (2) NO biases the motor system to reject and reposition food that resists swallowing; (3) if mechanically resistant food is not successfully swallowed, NO mediates the formation and expression of memories of food inedibility; (4) NO production at rest inhibits feeding, countering the effects of food stimuli exciting feeding. At a cellular level, NO-dependent channels contribute to the resting potential of neurons controlling food finding and food consumption. Increases in L-arginine after animals eat act as a post-feeding inhibitory signal, presumably by modulating NO production at rest. NO also signals non-feeding behaviors that are associated with feeding inhibition. Thus, depending on context, NO may enhance or inhibit feeding behavior. The different functions of NO may reflect the evolution of NO signaling from a response to tissue damage that was then elaborated and used for additional functions. These results suggest that in higher animals (1) elicited and background transmitter ...Continue Reading

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Citations

Sep 4, 2014·Journal of Computational Neuroscience·Kendrick M ShawHillel J Chiel
Mar 27, 2015·The European Journal of Neuroscience·Lei Ray ZhongVincent Rehder
Jun 27, 2015·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·T ShomratB Hochner
Jun 9, 2015·Micron : the International Research and Review Journal for Microscopy·Kálmán NacsaZoltán Serfőző
Nov 21, 2014·Journal of Neurophysiology·Miranda J CullinsHillel J Chiel
Jul 19, 2017·Learning & Memory·Harris A WeiszRiccardo Mozzachiodi
Oct 27, 2020·Frontiers in Aging Neuroscience·Nicholas S KronLynne A Fieber
Dec 11, 2020·Biological cybernetics·Victoria A Webster-WoodHillel J Chiel

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