Nitric oxide availability in deeply hypoxic crucian carp: acute and chronic changes and utilization of ambient nitrite reservoirs

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Marie N HansenFrank B Jensen

Abstract

Recent research suggest that anoxia-tolerant fish transfer extracellular nitrite into the tissues, where it is used for nitric oxide (NO) generation, iron-nitrosylation, and S-nitrosation of proteins, as part of the cytoprotective response toward prolonged hypoxia and subsequent reoxygenation. We hypothesized that crucian carp take up ambient nitrite and use it as a source of cellular NO availability during hypoxia. Fish were exposed for 1 day to normoxia (Po2 > 140 mmHg) and deep hypoxia (1 < Po2 < 3 mmHg) at both low (< 0.2 μM) and moderately elevated (10 μM) ambient [nitrite] to decipher NO metabolites in plasma and several tissues. We also compared NO metabolite changes during acute (10 min) and chronic (1 day) exposures to three different O2 levels. Plasma [nitrite] decreased with decreasing [O2], while the cellular concentrations of nitrite and nitros(yl)ated compounds either increased or stayed constant, depending on O2 level and tissue type. Nitrite was notably increased in the heart during deep hypoxia, and the increase was amplified by elevated ambient [nitrite]. Raised nitrite also increased gill [nitrite] and decreased mRNA expression of an inducible nitric oxide synthase-2 gene variant. The data support that ambien...Continue Reading

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Citations

Jul 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Paola CortiMark T Gladwin
Jan 23, 2017·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Frank B JensenTobias Wang
Jan 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lucie GerberSteffen S Madsen
May 1, 2018·Frontiers in Physiology·Alfonsina GattusoSandra Imbrogno
Jan 28, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christian CarnevaleA Kurt Gamperl
Aug 30, 2021·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Mariacristina FiliceSandra Imbrogno

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