PMID: 7546631Jun 1, 1995Paper

Nitric oxide-based possibilities for pharmacotherapy

Annals of Medicine
I Pörsti, I Paakkari

Abstract

The goal of nitric oxide (NO) based pharmacotherapy is to reach proper homeostasis of NO metabolism in the target tissue where endogenous production of NO is either too weak or excessively increased. In addition to the classic NO-based therapy of cardiovascular conditions with nitrates, a variety of new therapeutic possibilities have emerged including sexual disorders, gastrointestinal system, immunology, tumour growth regulation and respiratory disorders. NO levels of target tissues can be affected directly by NO donors, or indirectly by increasing the level of L-arginine, a substrate of nitric oxide synthase (NOS). While increased production of NO by induceable NO (iNOS) by, for example, cytokines does not at present seem therapeutically meaningful, increased NO production by constitutive NOS (cNOS) may be involved in the beneficial effects of ACE inhibitors or oestrogens. NO production may be pharmacologically decreased by inhibition of expression of iNOS by glucocorticoids while both cNOS and iNOS derived NO production is inhibited by administration of false substrates, for example L-NAME. Additionally, the respiratory system and related vessels can be reached directly and more selectively by inhalation of pure NO gas. Poss...Continue Reading

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K McMillanB S Masters
Dec 1, 1992·British Journal of Pharmacology·M S MulliganP A Ward
Jan 1, 1992·Journal of Cardiovascular Pharmacology·P VallanceS Moncada
Jan 1, 1992·Trends in Pharmacological Sciences·T McCall, P Vallance
Jun 1, 1992·The Journal of Urology·P A BushL J Ignarro
Apr 1, 1992·British Journal of Pharmacology·W Linz, B A Schölkens
Nov 1, 1992·Clinical Science·A J BradyT J Williams
Jun 27, 1992·Lancet·L FoubertT Higenbottam
Feb 1, 1992·British Journal of Pharmacology·J A MitchellJ R Vane
Jul 17, 1992·Science·A L BurnettS H Snyder
Aug 20, 1992·The New England Journal of Medicine·J M VanderwindenM H De Laet
Jul 1, 1992·American Journal of Hypertension·T YukimuraK Yamamoto
Jul 28, 1992·Biochemistry·K A White, M A Marletta
Sep 1, 1992·Annals of Neurology·T M DawsonS H Snyder
Sep 1, 1992·European Heart Journal·T F Lüscher
Oct 1, 1992·Hypertension·T ImaizumiA Takeshita
Jan 1, 1992·European Journal of Clinical Pharmacology·P VallanceJ Collier
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L MasferrerP Needleman
Jun 15, 1992·The American Journal of Cardiology·H DrexlerR Zelis
Feb 11, 1992·European Journal of Pharmacology·A IalentiM Di Rosa
Aug 1, 1992·Journal of the American College of Cardiology·J K WilliamsT B Clarkson

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Citations

Sep 1, 1996·Reviews in Medical Virology·R K FujimuraP Shapshak
Feb 21, 2002·Journal of Neurotrauma·Sean D HurleyM Kerry O'Banion
Dec 1, 1995·Journal of Clinical Pharmacy and Therapeutics·B HammarströmJ L Nilsson
Sep 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria S França-SilvaValdir A Braga
Nov 4, 2000·Expert Opinion on Investigational Drugs·L M Howe
Jun 23, 2005·The Journal of Pharmacy and Pharmacology·Jae Wook OhKeon Wook Kang
Oct 27, 2009·Biochemical Pharmacology·Nadine SchmidtHartmut Kleinert
Feb 21, 2006·Nitric Oxide : Biology and Chemistry·Yuba Raj PokharelKeon Wook Kang
Sep 25, 2012·Free Radical Biology & Medicine·Manuella LanzettiSamuel Santos Valença
Apr 29, 1998·The Veterinary Clinics of North America. Small Animal Practice·L M Howe
Apr 20, 2004·Journal of Cellular and Molecular Medicine·Noemi BarbutoCarlos Alberto Mandarim-de-Lacerda
Apr 17, 1998·Immunopharmacology and Immunotoxicology·M A PanaroO Brandonisio
Mar 21, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kazuya KinoshitaHideaki Karaki
Jun 2, 2007·Biological & Pharmaceutical Bulletin·Yuba Raj PokharelKeon Wook Kang
Dec 9, 1998·Journal of Biomedical Science·L M Pereira, C A Mandarim-de-Lacerda
Feb 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lu LuWeijia Xie
Feb 14, 1997·Journal of Medicinal Chemistry·G SorbaA Gasco
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·G M Tozer, S A Everett

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