PMID: 7546622Jun 1, 1995Paper

Nitric oxide: biological mediator, modulator and effector

Annals of Medicine
M W Radomski

Abstract

Nitric oxide (NO) is synthesized from L-arginine by at least three isoforms of NO synthase enzyme (NOS). Once generated NO can interact with a number of molecular targets including haem proteins, enzymes, DNA, thiols, oxygen and superoxide. These reactions determine the profile of NO as a major biological mediator, modulator and effector molecule.

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