Nitric oxide, cAMP and the biphasic muscarinic modulation of ACh release at the lizard neuromuscular junction

The Journal of Physiology
Austin R GravesClark A Lindgren

Abstract

In this study, we characterized the pharmacology and physiology of the automodulation of ACh release at the lizard neuromuscular junction (NMJ). The activation of muscarinic ACh receptors generated a biphasic modulation of synaptic transmission. Muscarine-induced activation of M3 receptors (0-12 min) decreased release, whereas M1 activation (> 12 min) enhanced release. Both phases of the biphasic effect are dependent on nitric oxide. However, cAMP acting via protein kinase A is also necessary for the M1 effect. In summary, we present a novel biphasic role for muscarine and implicate M3 receptors in the inhibition and M1 receptors in the enhancement of transmitter releaseat the cholinergic lizard NMJ.

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Citations

Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haipeng ZhuChristopher M Gomez
Oct 12, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Igor AntonovRobert D Hawkins
Apr 6, 2007·The European Journal of Neuroscience·Zachary NewmanClark Lindgren
Jul 1, 2008·The European Journal of Neuroscience·John Garthwaite
Feb 8, 2020·Biochemical and Biophysical Research Communications·Andrei N TsentsevitskyIrina V Kovyazina

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