Nitric oxide-dependent blood-brain barrier permeability alteration in the rat brain

Experientia
A ShuklaR C Srimal

Abstract

The role of nitric oxide (NO), a well known vasodilator, in the regulation of blood-brain barrier (BBB) permeability is not clear. Therefore, the present study was planned to assess the role of NO-releasing compounds like sodium nitroprusside (SNP) and the active metabolite of molsidomine, SIN-1, as well as a precursor on NO, L-arginine, on this physiological barrier. The permeability was assessed by using several tracers. All three agents increased the permeability of BBB to the tracer. The increase in permeability caused by L-arginine was not blocked by N-nitro-L-arginine methyl ester (L-NAME). L-Arginine-treated brains did not show an elevation of nitrite content, thus ruling out the possibility of NO generation and its involvement in BBB permeability alteration. It is concluded that NO itself causes an increase in the permeability of BBB. However, arginine-induced opening is not NO mediated.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T D OuryJ D Crapo
Dec 1, 1991·The Journal of Cell Biology·L L RubinJ Morales
Dec 31, 1991·Biochemical and Biophysical Research Communications·G M RubanyiL H Botelho
Jan 1, 1991·Annals of the New York Academy of Sciences·L L RubinJ Morales
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
May 31, 1988·Brain Research·J L Martinez, L Koda
Sep 1, 1987·Kidney International·R Hirschberg, J D Kopple
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D J Stuehr, M A Marletta
Jul 1, 1982·Pharmacological Research Communications·A GulatiK P Bhargava
Apr 1, 1993·Journal of Cellular Physiology·O Durieu-TrautmannP O Couraud
Jan 29, 1993·Biochemical and Biophysical Research Communications·X Chen, C N Gillis

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Citations

Feb 24, 2007·Cellular and Molecular Neurobiology·Atsushi YamauchiYasufumi Kataoka
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Mohamed B Abou-DoniaWasiuddin A Khan
Dec 29, 1998·Toxicology·T MinamiY Okazaki
Jun 27, 2000·Environmental Toxicology and Pharmacology·A GuptaG S Shukla1
Jun 9, 2001·Antioxidants & Redox Signaling·V E Thiel, K L Audus
May 31, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·W G Mayhan
Jul 10, 2003·Lancet Neurology·Kenneth J Smith, Hans Lassmann
Aug 10, 2000·Journal of Veterinary Internal Medicine·A A Webb, G D Muir
Sep 28, 2010·Progress in Retinal and Eye Research·Chung-Jung Chiu, Allen Taylor
Aug 6, 2010·Brain Research Reviews·Filipa Lourenço CardosoMaria Alexandra Brito
Oct 27, 2015·Frontiers in Psychology·Evert BoonstraSander Nieuwenhuis
Jun 17, 2014·Neuroscience and Biobehavioral Reviews·Mehdi Ghasemi, Ali Fatemi
Aug 3, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Eva Rosa PetersenAnnette Bang Oturai
Jan 19, 2018·Neurology·Eva R PetersenHelle B Søndergaard
Aug 12, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Krishnadas Madhu, Prakash T

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