Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress

Histochemistry and Cell Biology
Sanja Vignjević PetrinovićVladan Čokić

Abstract

Anaemia occurs frequently in patients with heart failure and its current treatment lacks clear targets. Emerging evidence suggests that erythroid progenitor cell expansion is an integral part of physiological response to anaemia associated with chronic stress. Understanding the underlying mechanism may provide a novel approach to anaemia management. In this study, we aimed to examine a role for nitric oxide (NO) in the regulation of bone marrow erythroid progenitor response to chronic stress. For this purpose, adult male mice were subjected to 2 h daily restraint stress for 7 or 14 consecutive days. The role of NO was assessed by subcutaneous injection with NG-nitro-L-arginine methyl ester, 30 min prior to each restraint. Chronic exposure to stress resulted in significantly increased number of bone marrow erythroid progenitors, and blockade of NO biosynthesis prior to daily stress completely prevented stress-induced erythroid progenitor cell expansion. Furthermore, chronic stress exposure led to altered expression of neural, endothelial and inducible nitric oxide synthases (NOS) in the bone marrow, both on mRNA and protein level. Decreased expression of neural and endothelial NOS, as well as reduced expression of NF-kappaB/p65 ...Continue Reading

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Citations

May 28, 2021·Physiological Reports·Yasminye D PettwayJennifer S Pollock

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Methods Mentioned

BETA
Protein Assay
PCR
nuclear translocation

Software Mentioned

Relative Expression Software Tool ( REST )
analysis Pro
Image Master Total

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