PMID: 7581266Jun 1, 1995Paper

Nitric oxide-dependent killing of Candida albicans by murine peritoneal cells during an experimental infection

FEMS Immunology and Medical Microbiology
A RementeriaM J Sevilla

Abstract

The phagocytic and candidacidal activities of the peritoneal cells of Candida albicans-infected mice were studied 20 days following experimental infection. Both activities were enhanced during infection. The production of nitric oxide (NO) by the peritoneal cells of infected mice was determined, and an increase in the nitrite concentration in supernatants of peritoneal cell cultures was detected. The period of NO production by the peritoneal cells coincided partially with the period of enhanced C. albicans killing. The inhibition of NO synthesis by N-monomethyl-L-arginine was concomitant with inhibition of candidacidal activity. We conclude that NO synthesis is the primary candidacidal mechanism of the murine peritoneal cells activated by C. albicans infection.

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Citations

Mar 22, 2005·International Immunopharmacology·M BulucE Demirel-Yilmaz
Dec 3, 1999·Microbes and Infection·G Del SeroL Romani
Jun 11, 2004·Eukaryotic Cell·Breanna D UllmannMichael C Gustin
Dec 20, 2013·The Journal of Experimental Biology·Alistair J P BrownMichelle D Leach
Apr 20, 2001·International Journal of Medical Microbiology : IJMM·K SchröppelC Bogdan
Jan 13, 2009·Cellular Microbiology·Elena Fernández-ArenasRosalía Diez-Orejas
Aug 4, 2004·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shigeru AbeHideyo Yamaguchi
Oct 18, 2011·Cellular and Molecular Life Sciences : CMLS·Yun Liang YangHsiu Jung Lo
Feb 7, 1998·FEMS Immunology and Medical Microbiology·A RementeríaM J Sevilla
Dec 1, 1995·Microbiological Reviews·R B Ashman, J M Papadimitriou

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