PMID: 8004386Feb 1, 1994Paper

Nitric oxide-dependent release of vasodilator quantities of calcitonin gene-related peptide from capsaicin-sensitive nerves in rabbit skin

British Journal of Pharmacology
S R Hughes, S D Brain

Abstract

1. Calcitonin gene-related peptide (CGRP) is a potent and long lasting vasodilator in the cutaneous microvasculature of many species including the rabbit. In this study we have investigated the role of nitric oxide in the release of endogenous CGRP, in response to capsaicin, in rabbit skin. 2. Cutaneous blood flow was measured in response to intradermally-injected agents by a multiple site 133Xenon clearance technique. 3. The increased blood flow induced by capsaicin (100 nmol/site) and CGRP (3 pmol/site) was totally inhibited by the CGRP antagonist CGRP(8-37) (1 nmol/site), whilst the increased blood flow induced by sodium nitroprusside (0.3, 1 and 3 nmol/site) was unaffected by CGRP(8-37). 4. The nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 30 nmol/site) had no effect on the vasodilator response induced by CGRP, but significantly inhibited capsaicin-induced blood flow. The inhibitory effect of L-NAME on capsaicin-induced blood flow was reversed by intradermal L-arginine (300 nmol/site), whilst the inactive enantiomer D-NAME (30 nmol/site) and the alpha-adrenoceptor agonist phenylephrine (10 pmol/site), at a dose which had a similar effect to L-NAME on basal blood flow, had no effect on capsaicin-i...Continue Reading

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Citations

Feb 19, 1997·European Journal of Pharmacology·M UchiyamaN Toda
Feb 28, 1998·Journal of the Autonomic Nervous System·R K PanditaK E Andersson
Feb 11, 1998·General Pharmacology·P Holzer
Apr 25, 2003·Medical Hypotheses·Yuan Jian Li, Yan Hua Du
Apr 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Martin Feelisch
Jul 25, 2009·Pancreas·Lutz SchneiderJens Werner
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Apr 12, 2011·Experimental Physiology·Brett J Wong, Christopher T Minson
Mar 28, 2008·European Journal of Pharmacology·Jun Peng, Yuan-Jian Li
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Sep 27, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Yoshitaka YamanakaTakamichi Hattori
Sep 6, 2008·Journal of the American College of Cardiology·Ulrich HinkThomas Münzel
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Jun 20, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Brett J WongArshed A Quyyumi

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