Nitric oxide depolarizes type II paraventricular nucleus neurons in vitro

Neuroscience
J S Bains, A V Ferguson

Abstract

Nitric oxide is a labile gas which has been implicated in neuronal signalling. The enzyme responsible for the production of this molecule is present in the paraventricular nucleus of the hypothalamus, yet a specific role for nitric oxide in neurotransmission within this nucleus remains unclear. Using whole-cell patch-clamp recordings from paraventricular nucleus neurons in a coronal hypothalamic slice, we have assessed the acute effects of nitric oxide on membrane potential and ionic conductance. Recordings were obtained from 78 neurons with a mean resting membrane potential of -57.8 +/- 0.6 mV and a mean input resistance of 972 +/- 146 M omega. Cells were electrophysiologically classified into Type I or Type II according to previously established criteria. Bath application of nitric oxide (delivered either as a gas dissolved in solution, or liberated from the donor compound, N-acetyl-S-nitroso-D-penicillamine) elicited reversible membrane depolarizations (3 mV) in 14 of the 19 Type II cells tested. These cells also exhibited a decrease in input resistance following nitric oxide application. Similar effects were observed in response to bath application of L-arginine, with 11 of 14 cells displaying depolarizations and accompanyi...Continue Reading

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