Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model

Cancer Research
Nengtai OuyangBasil Rigas

Abstract

To evaluate the chemopreventive effect of nitric oxide-donating aspirin (NO-ASA), an ASA bearing a NO-releasing moiety, against pancreatic cancer, we studied six groups of female Syrian golden hamsters: groups 1 to 3 (n = 12 each) were given saline and groups 4 to 6 (n = 17) the carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) s.c. in five weekly injections (the first, 70 mg/kg, and the remaining, 20 mg/kg each). Control and BOP-treated hamsters were fed a NO-ASA 3,000 ppm or conventional ASA 3,000 ppm or control diet for 19 weeks. Groups 1 to 3 had no tumors. Compared with the BOP/vehicle group, NO-ASA reduced the incidence (88.9%, P < 0.003) and multiplicity (94%, P < 0.05) of pancreatic cancer; ASA had no statistically significant effect. NO-ASA arrested the transition from PanIN2 to PanIN3 and carcinoma. The proliferation (proliferating cell nuclear antigen) / apoptosis (terminal deoxyribonucleotide transferase-mediated nick-end labeling) ratio of ductal cells increased with the histologic severity of the ductal lesion; NO-ASA suppressed it significantly during all stages except PanIN1A. p21(WAF1/CIP1), undetectable in normal cells, was progressively induced in neoplastic cells and suppressed by NO-ASA up to PanIN3. Nuclear ...Continue Reading

References

May 9, 2001·The American Journal of Surgical Pathology·R H HrubanG J Offerhaus
Aug 8, 2002·Journal of the National Cancer Institute·Kristin E AndersonAaron R Folsom
Sep 6, 2002·BMC Public Health·Ravi J MenezesKirsten B Moysich
Dec 31, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·William W TsengCarson D Liu
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Fumio FurukawaMasao Hirose
Mar 8, 2003·International Journal of Gastrointestinal Cancer·Hana AlgülRoland M Schmid
Mar 26, 2003·Seminars in Cancer Biology·Anning Lin, Michael Karin
Apr 10, 2003·Free Radical Biology & Medicine·David A Wink, James B Mitchell
Aug 12, 2003·International Journal of Gastrointestinal Cancer·Andrew M Lowy
Oct 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Niharika NathBasil Rigas
Jan 8, 2004·Journal of the National Cancer Institute·John A Baron
Feb 6, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Marc B Hershenson
Jul 10, 2004·Trends in Molecular Medicine·Basil Rigas, Khosrow Kashfi
Aug 3, 2004·The Cancer Journal·Jason R Mann, Raymond N DuBois
Nov 30, 2004·Biochemical and Biophysical Research Communications·Niharika NathKhosrow Kashfi
Feb 5, 2005·Journal of Translational Medicine·Anna TeseiWainer Zoli
May 19, 2005·Cancer Research·Andrei L Gartel, Senthil K Radhakrishnan
Sep 20, 2005·The Journal of Pharmacology and Experimental Therapeutics·Thomas R Hundley, Basil Rigas
Nov 4, 2005·Carcinogenesis·Jianjun GaoBasil Rigas
Nov 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jianjun GaoBasil Rigas

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Citations

Nov 2, 2012·Cancer Metastasis Reviews·Wanglong Qiu, Gloria H Su
Jun 24, 2006·Nature Reviews. Cancer·Dai FukumuraRakesh K Jain
Feb 7, 2008·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Brandon G BentzG Kenneth Haines
Nov 29, 2013·International Journal of Oncology·Onika T MurrayBasil Rigas
Sep 12, 2013·Cancer Letters·Ibrahim Halil SahinChristopher R Garrett
Mar 26, 2011·Cancer Prevention Research·Michael A McIlhattonRichard Fishel
Jul 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Niharika NathKhosrow Kashfi
Sep 8, 2010·Seminars in Oncology·Vernon E Steele, Ronald A Lubet
May 22, 2007·Biochemical and Biophysical Research Communications·Khosrow Kashfi, Basil Rigas
Jun 2, 2018·Medicinal Research Reviews·Hui HuaYangfu Jiang
Aug 11, 2017·Chemistry & Biodiversity·Lanyue ZhangZhiyun Du
Oct 25, 2007·Biochemical Society Transactions·B Rigas
Aug 12, 2016·Antioxidants & Redox Signaling·Jian Wang, S Perwez Hussain

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