Nitric Oxide Donor-Based Cancer Therapy: Advances and Prospects

Journal of Medicinal Chemistry
Zhangjian HuangYihua Zhang

Abstract

The increasing understanding of the role of nitric oxide (NO) in cancer biology has generated significant progress in the use of NO donor-based therapy to fight cancer. These advances strongly suggest the potential adoption of NO donor-based therapy in clinical practice, and this has been supported by several clinical studies in the past decade. In this review, we first highlight several types of important NO donors, including recently developed NO donors bearing a dinitroazetidine skeleton, represented by RRx-001, with potential utility in cancer therapy. Special emphasis is then given to the combination of NO donor(s) with other therapies to achieve synergy and to the hybridization of NO donor(s) with an anticancer drug/agent/fragment to enhance the activity or specificity or to reduce toxicity. In addition, we briefly describe inducible NO synthase gene therapy and nanotechnology, which have recently entered the field of NO donor therapy.

References

Feb 15, 1991·Biochemical Pharmacology·L J Ignarro
Nov 1, 1993·American Journal of Clinical Pathology·F L Kiechle, T Malinski
Mar 1, 1994·The Biochemical Journal·R G Knowles, S Moncada
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A GellerT R Billiar
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MalinskiM Chopp
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·K ForresterC C Harris
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Apr 1, 1997·Nitric Oxide : Biology and Chemistry·K D KrönckeV Kolb-Bachofen
Jul 3, 1999·The Journal of Biological Chemistry·S GlockzinB Brüne
Jan 29, 2000·Journal of Medicinal Chemistry·J E SaavedraL K Keefer
Oct 25, 2000·The Journal of Gene Medicine·M N SolerS Lausson
Mar 21, 2002·The Lancet Oncology·P K Lala, C Chakraborty
Apr 11, 2002·Chemical Reviews·Peng George WangAdam J Janczuk
May 30, 2002·Biological Chemistry·Clinton S Boyd, Enrique Cadenas
Dec 28, 2002·Journal of Medicinal Chemistry·Marcy Hernick, Richard F Borch
Nov 8, 2003·Bioorganic & Medicinal Chemistry·Tingwei Bill CaiPeng George Wang
Mar 17, 2004·Cardiovascular Research·Antonio Martínez-Ruiz, Santiago Lamas
Jun 2, 2004·The Journal of Gene Medicine·Jenny WorthingtonDavid G Hirst
Jul 10, 2004·Trends in Molecular Medicine·Basil Rigas, Khosrow Kashfi
Jul 13, 2004·Cancer Treatment Reviews·S DansonM Ranson
Sep 29, 2004·Free Radical Biology & Medicine·Gregory R J ThatcherVioleta Toader
Nov 5, 2004·Organic Letters·T Bill CaiPeng George Wang
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zhiqiang ChenJonathan S Stamler
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hiroyasu YasudaHidetada Sasaki
Jun 20, 2006·Archiv der Pharmazie·Chang ChenPeng George Wang
Jun 24, 2006·Nature Reviews. Cancer·Dai FukumuraRakesh K Jain
Jul 11, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Benjamin BonavidaHermes Garbán
Sep 23, 2006·Medicinal Research Reviews·Simone MocellinDonato Nitti
Apr 3, 2007·British Journal of Pharmacology·M R Miller, I L Megson
Apr 29, 2008·Free Radical Biology & Medicine·Douglas D ThomasDavid A Wink

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Citations

Jul 1, 2017·Expert Opinion on Drug Discovery·Ricardo A M SerafimElizabeth I Ferreira
Apr 11, 2018·ChemMedChem·Federica SodanoSalvatore Sortino
Dec 2, 2017·Chemical Communications : Chem Comm·Govindan RavikumarHarinath Chakrapani
Jul 17, 2018·Journal of Cellular and Molecular Medicine·Bryan OronskyPedro Cabrales
Aug 25, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Aurore Fraix, Salvatore Sortino
Nov 30, 2018·Anti-cancer Drugs·Florencia PérezPaola Hernández
Apr 30, 2019·Biomaterials Science·Milo MalangaSalvatore Sortino
May 11, 2019·Chemistry : a European Journal·Cristina ParisiSalvatore Sortino
Sep 12, 2019·Chemistry : a European Journal·Egor S ZhilinNina N Makhova
Nov 14, 2019·Current Topics in Medicinal Chemistry·Ricardo Pereira RodriguesRodrigo Rezende Kitagawa
Feb 25, 2020·The Journal of International Medical Research·Ya HuXi Tang
May 27, 2020·Chemistry : a European Journal·Cristina ParisiSalvatore Sortino
Sep 20, 2019·Antioxidants·Emily Hays, Benjamin Bonavida
Nov 11, 2019·Antioxidants·Loretta LazzaratoSalvatore Sortino
Oct 28, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Xiangyu JiaoYongqiang Wen
Jan 18, 2020·Biomolecules·Yuma YamadaHideyoshi Harashima
Aug 8, 2018·Disease Models & Mechanisms·Rom Keshet, Ayelet Erez
Feb 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lu LuWeijia Xie
Dec 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weizhi GeQuan Zhang
May 8, 2018·Medicinal Research Reviews·Heba M HeshamKhaled A M Abouzid
Dec 14, 2018·Chemical Communications : Chem Comm·Yang ZhouMark E Meyerhoff
Aug 27, 2019·Frontiers in Oncology·Sai LiKang Peng
Aug 30, 2020·Antioxidants·Long Binh Vong, Yukio Nagasaki
Oct 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sana WaheedViqar Syed
Oct 10, 2019·Pharmaceutical Nanotechnology·Houman AlimoradiGregory I Giles
Oct 21, 2020·European Journal of Medicinal Chemistry·Amr K A BassGamal El-Din A Abuo-Rahma
Dec 11, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yana ShafranNaomi Zurgil
Nov 5, 2020·European Journal of Medicinal Chemistry·Gargi Nikhil VaidyaDinesh Kumar

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