Abstract
Rupture-prone atherosclerotic plaques are characterized by a thin fibrous cap containing numerous macrophage-derived foam cells and few smooth muscle cells (SMC). Decreasing the ratio between macrophages and SMC might favor plaque stabilization. Macrophages expressing inducible nitric oxide (NO) synthase become hypersensitive to killing by exogenous NO donors. Therefore, we investigated in cholesterol-fed rabbits (20 weeks 0.3% cholesterol) the effect of 4 weeks cholesterol withdrawal alone and in combination with the NO donor molsidomine on plaque size, cell composition, superoxide production and extracellular superoxide dismutase (ecSOD) mRNA expression in the atherosclerotic plaques in the aorta. Cholesterol withdrawal alone did not alter atherosclerotic plaque size, the increased superoxide production or the decreased ecSOD mRNA, but led to the formation of a thin subendothelial macrophage-free layer and reduced both vascular cell adhesion molecule-1 expression and cell replication in the luminal part of the plaques. Treatment with molsidomine (1 mg/kg/day) during cholesterol withdrawal did not affect plaque size but increased the thickness of the subendothelial macrophage-free layer consisting of SMC, and normalized both s...Continue Reading
References
Jan 1, 1989·Journal of Cardiovascular Pharmacology·M FeelischE Noack
Aug 1, 1995·Journal of Cardiovascular Pharmacology·G R De MeyerA G Herman
Feb 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·R P BrandesA Mügge
Nov 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·P StrålinS L Marklund
Apr 1, 1995·British Journal of Pharmacology·H BultA G Herman
Dec 1, 1994·Journal of Cardiovascular Pharmacology·A MüggeP R Lichtlen
Sep 15, 1996·Circulation·M M KockxA Herman
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·S MohrE G Lapetina
Aug 26, 1998·Circulation·A DanaD M Yellon
Aug 26, 1998·The Journal of Biological Chemistry·Y XiaJ L Zweier
Aug 29, 1998·Circulation Research·M M KockxA G Herman
Oct 1, 1998·European Journal of Pharmacology·G KojdaE Noack
Nov 21, 1998·Free Radical Biology & Medicine·L BenovI Fridovich
Jan 12, 1999·Archives of Biochemistry and Biophysics·R J SinghB Kalyanaraman
Feb 25, 1999·Atherosclerosis·D BehrT J Verbeuren
Jun 5, 1999·Archives of Biochemistry and Biophysics·I B Afanas'evL G Korkina
Jul 21, 1999·Circulation·J BauersachsG Ertl
Jun 7, 2000·The Journal of Clinical Investigation·T FukaiD G Harrison
Feb 22, 2001·Circulation·M CrisbyJ Nilsson
Feb 24, 2001·Circulation·M AikawaP Libby
Feb 27, 2001·Circulation·S Sastry, C McCollum
Apr 20, 2001·British Journal of Pharmacology·A HackerG Kojda
Jul 13, 2002·Circulation Research·Tamara M ParaviciniGrant R Drummond
Sep 25, 2002·Circulation·Brian J CareyRonney B Panerai
Citations
Oct 13, 2005·Journal of Cardiovascular Pharmacology·Shane A Phillips, Julian H Lombard
Jan 7, 2010·Journal of Cardiovascular Pharmacology·Valerie CroonsGuido R Y De Meyer
Feb 27, 2007·Vascular Health and Risk Management·Hong Ding, Chris R Triggle
Feb 24, 2007·Vascular Health and Risk Management·Greg J Dusting, Chris Triggle
Oct 22, 2013·Journal of Cardiovascular Translational Research·Emanuele BarbatoWilliam Wijns
Feb 13, 2007·Trends in Cardiovascular Medicine·Wim MartinetGuido R Y De Meyer
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ana Rodriguez-PeñaJose M Lopez-Novoa
Aug 19, 2007·British Journal of Pharmacology·W MartinetG R Y De Meyer
Feb 9, 2012·British Journal of Clinical Pharmacology·Inge De MeyerGuido R Y De Meyer
Mar 23, 2011·British Journal of Pharmacology·Wim MartinetGuido R Y De Meyer
May 25, 2005·Atherosclerosis·Cor Van HoveArnold G Herman
Apr 16, 2015·Atherosclerosis·Emanuele BarbatoWilliam Wijns
Oct 9, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Stefan VerheyeGuido R Y De Meyer
Nov 15, 2008·American Journal of Hypertension·Mònica GuxensMaría-Isabel Covas
Mar 31, 2007·Circulation Research·Wim Martinet, Guido R Y De Meyer
May 25, 2005·European Heart Journal·Arnold G Herman, Salvador Moncada
Aug 20, 2005·Pharmacological Reviews·Noboru Toda, Arnold G Herman
Mar 7, 2008·The Journal of Pharmacology and Experimental Therapeutics·Valerie CroonsGuido R Y De Meyer
Jan 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Rayomand S KhambataAmrita Ahluwalia
Apr 26, 2019·Frontiers in Pharmacology·Wim MartinetGuido R Y De Meyer
Apr 17, 2020·International Journal of Molecular Sciences·Tommaso Gori