Nitric oxide donors: effects on fetoplacental blood flow

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Chistiane KählerHans-Joachim Seewald

Abstract

To investigate fetal and uteroplacental blood flow after transdermal administration of glyceroltrinitrate (GTN) in pregnancies at risk for preterm delivery. Twenty-five pregnant women who received GTN patches (Nitroderm TTS 10) with a dosage of 0.8 mg/h, because of risk for preterm delivery, were included in the prospective study. Doppler measurements (resistance index, RI) of the umbilical artery (UA), the middle cerebral artery (MCA) and the uterine arteries of the placental (UTA-P) and the non-placental (UTA-NP) side, with calculation of the mean-RI (UTA-mean), were performed before and after 24, 48 and 72 h of the 1st GTN application. Wilcoxon test and Holm correction were used for statistical analysis. The initial RI values were in the normal range. Significant decreases of the RI of UTA-NP ( P = 0.02 ) and UTA-mean ( P = 0.03) were observed 24h after GTN application. The other RI values did not show significant changes. Transdermal nitroglycerine used for the treatment of preterm labour does only reduce uterine vascular impedance at the non-placental side with primary higher resistance. It does not affect fetal perfusion and uterine perfusion at the placental side with normal blood flow resistance.

References

Feb 1, 1991·British Journal of Pharmacology·G ChaudhuriL J Ignarro
Feb 1, 1991·American Journal of Obstetrics and Gynecology·L MyattD E Brockman
Oct 1, 1989·British Journal of Obstetrics and Gynaecology·K P HanrettyM J Whittle
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
May 1, 1995·American Journal of Obstetrics and Gynecology·H IzumiR E Garfield
Jun 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y MakinoK Shirakawa
Aug 1, 1997·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J KurmanaviciusA Huch
Oct 23, 1997·British Journal of Obstetrics and Gynaecology·R Di IorioE V Cosmi
Nov 20, 1998·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C LeesS Campbell
Sep 7, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·E BeinderC Baylis
Sep 24, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G LuziG C Di Renzo

❮ Previous
Next ❯

Citations

Mar 17, 2010·Reproductive Sciences·Sarah A HaleIra M Bernstein
Jul 16, 2014·European Heart Journal·Giuseppe PattiUNKNOWN Working Group on Thrombosis of the Italian Society of Cardiology
Jul 21, 2012·Cardiology Clinics·Gagan Sahni
Mar 5, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A TrapaniM M de S Pires
Jan 24, 2007·American Journal of Obstetrics and Gynecology·Graeme N SmithUNKNOWN Canadian Preterm Labour Nitroglycerin Trial Group
Jul 12, 2008·Journal of the American College of Cardiology·Arie Roth, Uri Elkayam
Aug 19, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A TrapaniM M S Pires
Aug 4, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Viviana de PaceFabio Facchinetti
Apr 27, 2011·Expert Review of Cardiovascular Therapy·Mohammed El-DeebKadhim Sulaiman
Oct 31, 2012·Current Opinion in Obstetrics & Gynecology·Madhavi KalidindiJoseph Aquilina
Feb 5, 2008·Annals of Medicine·Mervi R H Väisänen-Tommiska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.