PMID: 11899431Mar 20, 2002Paper

Nitric oxide-enhanced resistance to oral candidiasis

Immunology
S ElahiRobert Clancy

Abstract

A murine model of oral candidiasis was used to show that nitric oxide (NO) is involved in host resistance to infection with Candida albicans in infection-'resistant' BALB/c and infection-'prone' DBA/2 mice. Following infection, increased NO production was detected in saliva. Postinfection samples of saliva inhibited the growth of yeast in vitro. Treatment with NG-monomethyl-L-arginine (MMLA), an inhibitor of NO synthesis, led to reduced NO production, which correlated with an increase in C. albicans growth. Reduction in NO production following MMLA treatment correlated with an abrogation of interleukin-4 (IL-4), but not interferon-gamma (IFN-gamma), mRNA gene expression in regional lymph node cells. Down-regulation of IL-4 production was accompanied with an increase in IFN-gamma production in infection-'prone' DBA/2 mice. There was a functional relationship between IL-4 and NO production in that mice treated with anti-IL-4 monoclonal antibody showed a marked inhibition of NO production in saliva and in culture of cervical lymph node cells stimulated with C. albicans antigen. The results support previous conclusions that IL-4 is associated with resistance to oral candidiasis and suggest that NO is involved in controlling coloniz...Continue Reading

References

Oct 1, 1979·American Journal of Clinical Pathology·S Y Cho, H Y Choi
Jul 1, 1991·Infection and Immunity·M T Cantorna, E Balish
Nov 1, 1991·The Journal of Infectious Diseases·M T Cantorna, E Balish
Apr 1, 1990·Infection and Immunity·M T Cantorna, E Balish
Mar 1, 1989·Journal of Medical Microbiology·E Brummer, D A Stevens
Jul 28, 1986·The American Journal of Medicine·G P Bodey
Jan 1, 1984·Reviews of Infectious Diseases·J B EpsteinK T Izutzu
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Mar 1, 1995·Immunology Today·P J Barnes, F Y Liew
Jul 1, 1995·The Journal of Infectious Diseases·A Vazquez-TorresE Balish
Jun 1, 1995·Current Opinion in Immunology·F Y Liew
Mar 1, 1995·Infection and Immunity·A Vazquez-TorresE Balish
Jul 1, 1994·The Journal of Infectious Diseases·A Vazquez-TorresE Balish
Jul 1, 1993·Infection and Immunity·P S HiemstraR I Lehrer
Dec 1, 1996·Infection and Immunity·A MencacciL Romani

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Citations

Apr 6, 2004·Immunology and Cell Biology·Robert B AshmanRobert L Clancy
Jul 15, 2005·Molecular Biology of the Cell·Aaron Sarver, Joseph DeRisi
Jun 11, 2004·Eukaryotic Cell·Breanna D UllmannMichael C Gustin
Nov 6, 2010·Clinical & Developmental Immunology·Robert B AshmanChristine A Wells
Jun 19, 2012·The Journal of Clinical Investigation·Sixto M LealEric Pearlman
Dec 8, 2009·Journal of Periodontology·Valéria GelaniAna Paula Campanelli
May 27, 2009·Medical Mycology·Venessa TessarolliAna Paula Campanelli
Jun 16, 2009·Scandinavian Journal of Immunology·J VenturiniM S P de Arruda
Oct 22, 2005·Oral Microbiology and Immunology·C S Farah, R B Ashman
Jan 13, 2009·Cellular Microbiology·Elena Fernández-ArenasRosalía Diez-Orejas
Apr 2, 2011·Gerodontology·Thaís H GasparotoVanessa S Lara
Aug 4, 2004·Current Opinion in Microbiology·Louis de Repentigny
Jan 28, 2006·FEMS Microbiology Reviews·James P BurnieRuth C Matthews
Jul 21, 2009·Current Opinion in Microbiology·Alistair J P BrownJanet Quinn
Apr 22, 2008·FEMS Microbiology Letters·Julian R NaglikFrank C Odds
Oct 22, 2014·PloS One·Shokrollah ElahiVolker Gerdts
Mar 23, 2017·Frontiers in Immunology·Samantha E Heron, Shokrollah Elahi
May 15, 2010·Medical Mycology·Thaís Helena GasparotoAna Paula Campanelli

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