PMID: 8971784Nov 22, 1996Paper

Nitric oxide enhances amino acid release from immature chick embryo retina

Neuroscience Letters
R IentileS Macaione

Abstract

Nitric oxide (NO) was investigated for its ability to induce amino acid release from immature chick retina. The production of endogenous NO by activation of NO synthase after stimulation of N-methyl-D-aspartate (NMDA) subtype of glutamate receptor caused a significant increase in basal release of gamma-aminobutyric acid (GABA) and glutamine, whereas a more modest increase in the glutamate release was also observed. The exposure of chick retina from 9-day-old embryos to NO-generating compounds, S-nitroso-N-acetylpe-nicillamine (SNAP) and sodium nitroprusside (SNP) produced a dose dependent increase in GABA, glutamine, and glutamate release. This effect was reduced by about 80% by haemoglobin. These results indicate that NO has a stimulatory effect on amino acid release from chick embryo immature retina. However, this effect does not appear to involve a cGMP-related mechanism because 8-bromo-cGMP, a stable analogue of cGMP, failed to affect spontaneous amino acid release and because zaprinast did not enhance NMDA-stimulated release. In conclusion, our present observations may account for a role of NMDA-mediated events in the biochemical maturation under depolarizing conditions.

References

Oct 1, 1976·Journal of Neurochemistry·F G De MelloM Nirenberg
Oct 31, 1991·Biochemical and Biophysical Research Communications·C M VenturiniS Moncada
Aug 1, 1988·Trends in Neurosciences·Y A Barde
Jul 1, 1989·Trends in Neurosciences·S A Lipton, S B Kater
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaN A Lassen
Sep 1, 1994·American Journal of Obstetrics and Gynecology·C P WeinerS Moncada
Jan 22, 1996·FEBS Letters·R IentileS Macaione

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Citations

Mar 21, 2000·Journal of Neuroscience Research·O GoureauY Courtois
Jan 18, 2013·Cellular and Molecular Neurobiology·Mauro LeonelliLuiz R G Britto
Feb 27, 2001·Neurochemistry International·R A KowluruT S Kern
Dec 6, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cristiane R MagalhãesRoberto Paes-de-Carvalho

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