PMID: 9479625Jan 1, 1997Paper

Nitric oxide, histamine, and sensory nerves in the acid secretory response in rat stomach after damage

Journal of Clinical Gastroenterology
K TakeuchiM Tsuchimoto


The stomach normally responds to mucosa-damaging agents by decreasing acid secretion, but this acid response turn from "inhibition" into "stimulation" when the production of nitric oxide (NO) is inhibited by NG-nitro-L-arginine methyl ester (L-NAME). We investigated the mechanism underlying stimulation of acid secretion in the stomach after damage with taurocholate (TC) in the presence of L-NAME. A rat stomach was mounted in an ex vivo chamber and perfused with saline, and the potential difference (PD), luminal pH, and acid secretion were measured before and after application of 20 mM TC for 30 min. Exposure of the stomach to TC caused a reduction in PD, an increase in luminal pH, and a decrease in acid secretion. Pretreatment with L-NAME did not affect basal acid secretion but significantly increased secretion after damage with TC, without any effect on PD. This effect of L-NAME was antagonized by co-administration of L-arginine but not D-arginine. The luminal appearance of NO was also increased after exposure of the stomach to TC, a phenomenon completely blocked by L-NAME, or when EGTA was applied together with TC. The enhanced acid secretory response in the presence of L-NAME was inhibited by prior administration of cimetidi...Continue Reading


Dec 19, 1989·European Journal of Pharmacology·J M PiqueJ V Esplugues
Sep 1, 1989·Gastroenterology·R H SteadJ Bienenstock
Apr 1, 1986·Digestive Diseases and Sciences·K TakeuchiS Okabe
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Feb 1, 1995·Digestive Diseases and Sciences·B I HirschowitzG Sachs
Feb 1, 1996·Gastroenterology·D J Ahnen

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Oct 15, 2008·Arquivos De Gastroenterologia·Paula Yuri Sugishita KanikadanWothan Tavares de Lima

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