Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation

Biochemical and Biophysical Research Communications
K TsudaY Masuyama

Abstract

It has been shown that rheological abnormality might be an etiological factor in hypertension. Recent studies have revealed that human erythrocytes possess a nitric oxide (NO) synthase and that this activation might be involved in the regulation of rheological properties of erythrocytes. The present study was undertaken to investigate the role of NO in the regulation of membrane functions of erythrocytes in patients with essential hypertension by means of an electron paramagnetic resonance (EPR) and spin-labeling method. The NO donor S-nitroso-N-acetylpenicillamine (SNAP) decreased the order parameter (S) for 5-nitroxide stearate (5-NS) and the peak height ratio (h(0)/h(-1)) for 16-NS obtained from EPR spectra of erythrocyte membranes in a dose-dependent manner. The finding indicated that the NO donor increased the membrane fluidity of erythrocytes. In addition, the effect of SNAP was significantly potentiated by 8-bromo-cyclic guanosine monophosphate. By contrast, the change of the fluidity induced by SNAP was reversed in the presence of L-N(G)-nitroarginine methyl ester and asymmetric dimethyl L-arginine. In patients with essential hypertension, the membrane fluidity of erythrocytes was significantly lower than in the normote...Continue Reading

References

Aug 18, 1977·The New England Journal of Medicine·R A Cooper
Dec 1, 1991·Hypertension·A F DominiczakD F Bohr
Aug 1, 1991·Hypertension·S T Turner, V V Michels
Feb 1, 1984·Journal of Hypertension·Y V Postnov, S N Orlov
Mar 30, 1993·European Journal of Pharmacology·R Korbut, R J Gryglewski
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B SpinnewynP E Chabrier

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Citations

Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Kazushi TsudaIchiro Nishio
Jan 25, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Nadezhda N BarvitenkoRoy E Weber
Dec 3, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kyoko AriyoshiNobuhiro Uyesaka
Jun 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K TsudaY Masuyama
Dec 24, 2008·European Journal of Clinical Pharmacology·S NagassakiJ E Tanus-Santos
Dec 9, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Pablo Muriel, Jazmin M Pérez-Rojas
Jun 22, 2010·Nitric Oxide : Biology and Chemistry·Pannuru PadmavathiNallanchakravarthula Varadacharyulu
Apr 4, 2007·Pathophysiology : the Official Journal of the International Society for Pathophysiology·O G LunevaE I Chazov
Feb 24, 2007·The American Journal of Cardiology·Tae H HanJames C Liao
Apr 20, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·O V RodnenkovE I Chazov
Jul 2, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Rosita GabbianelliElisabetta Damiani
Jul 28, 2006·Hearing Research·Guang-Di Chen, Hong-Bo Zhao
Sep 12, 2015·Biological Trace Element Research·Qiuyue ZhangYanfei Li
Dec 29, 2006·Journal of Atherosclerosis and Thrombosis·Taro Kuwai, Junichi Hayashi
Oct 31, 2006·Biochimica Et Biophysica Acta·Regina AlemanyValentina Ruiz-Gutierrez
Aug 13, 2010·Diabetes Research and Clinical Practice·D Simmons
Nov 29, 2016·Antioxidants & Redox Signaling·Viktoria KuhnMiriam M Cortese-Krott
Jun 4, 2002·Nature Medicine·Timothy J McMahonJonathan S Stamler
Jun 6, 2009·Stroke; a Journal of Cerebral Circulation·Kazushi Tsuda
May 2, 2009·Stroke; a Journal of Cerebral Circulation·Kazushi Tsuda
Oct 14, 2006·Stroke; a Journal of Cerebral Circulation·Kazushi Tsuda
Sep 27, 2008·Stroke; a Journal of Cerebral Circulation·Kazushi Tsuda
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Jan BalzerMalte Kelm
Nov 2, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazushi Tsuda
Nov 6, 2007·Cell Biology International·Joanna Brzeszczynska, Krzysztof Gwozdzinski
Nov 25, 2003·American Journal of Physiology. Renal Physiology·Hisanobu AdachiTakaaki Abe
Jun 4, 2018·Acta Biochimica Et Biophysica Sinica·Yajin ZhaoMan Hou
Dec 20, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Andreas FriebeAchim Schmidtko

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