PMID: 7546624Jun 1, 1995Paper

Nitric oxide in cardiovascular diseases

Annals of Medicine
E NavaT F Lüscher

Abstract

Nitric oxide (NO), synthesized from L-arginine by a family of NO synthases (NOS), is a widespread biological mediator implicated in many physiological and pathophysiological processes, including a variety of cardiovascular diseases. Endothelium-derived NO, synthesized by a constitutive NOS, is involved in hypertension, atherosclerosis and certain heart diseases. In hypertension and atherosclerosis the role of NO is still controversial and seems to vary depending on the stage of the disease and model studied. In spontaneous hypertension, the production of NO is increased, but inefficacious, probably because of increased inactivation. In salt-induced hypertension NO production may be impaired. In atherosclerosis, an enhanced degradation of NO by superoxide radicals may explain the reduced endothelium-dependent relaxations. In pulmonary hypertension, the use of NO gas inhalation has been proposed as a future therapy for this condition. In the heart, NO regulates coronary flow and myocardial function; both functions are altered in coronary artery disease and cardiomyopathy. Nitric oxide synthesized by the inducible NOS takes part in several immunopathological diseases, such as endotoxin shock, which can particularly affect the hear...Continue Reading

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·E NavaS Moncada
Jul 1, 1992·Acta Physiologica Scandinavica·S Moncada
Jan 1, 1992·Cardiovascular Research·C E WrightS Moncada
Jan 1, 1992·British Journal of Pharmacology·R M PalmerS Moncada
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K NakazonoM Inoue
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Nov 27, 1990·European Journal of Pharmacology·T J VerbeurenA G Herman
Dec 16, 1991·Biochemical and Biophysical Research Communications·L E GustafssonS Moncada
Sep 1, 1991·British Journal of Pharmacology·R SchulzS Moncada
Dec 1, 1991·The American Journal of Physiology·J G WongD E Johnson
Dec 1, 1991·European Journal of Clinical Investigation·A Billiau, F Vandekerckhove
Oct 1, 1990·British Medical Bulletin·N Woolf
Aug 21, 1990·European Journal of Pharmacology·N P WiklundP Hedqvist
Dec 1, 1990·Circulation Research·X J GirerdM A Creager
Dec 1, 1990·The Journal of Clinical Investigation·R L MinorD G Harrison
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R G KilbournR F Lodato
Sep 1, 1990·The Journal of Clinical Investigation·P A SobotkaJ X Thomas
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Jan 4, 1989·Journal of the National Cancer Institute·R NoraH J Silverman
Oct 1, 1989·The Journal of Clinical Investigation·S Ylä-HerttualaD Steinberg
Mar 1, 1989·The American Journal of Physiology·J A OsborneA M Lefer
Jan 1, 1994·Cardiovascular Research·A PetrosP Vallance
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·C P WeinerS Moncada
Aug 1, 1994·Stroke; a Journal of Cerebral Circulation·S BlotJ B Michel

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Citations

Oct 30, 1999·Heart and Vessels·M S CragoJ E McKenzie
Apr 9, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·E B ManukhinaA F Vanin
Jan 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F Baxter
Jul 1, 1998·Clinical Biochemistry·G EllisS K Makela
Mar 27, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A C BolteG A Dekker
May 1, 1997·British Journal of Pharmacology·I P FouyasI R Whittle
Dec 8, 2007·Journal of Applied Physiology·M Harold LaughlinShawn B Bender
Mar 20, 2002·The Journal of Clinical Investigation·Imran N MungrueMansoor Husain
May 17, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Seiji MaedaMitsuo Matsuda
Feb 1, 2000·Journal of Molecular and Cellular Cardiology·M S SumerayD M Yellon
Jun 12, 2003·Clinical and Experimental Hypertension : CHE·Ujendra KumarAnita Sidhu
Apr 30, 1998·Current Eye Research·Z ChenM S Cynader
Mar 19, 2005·Clinical and Experimental Hypertension : CHE·Ujendra KumarAnita Sidhu
Aug 12, 2008·Vascular Pharmacology·Anuran ChatterjeeJohn D Catravas
Sep 30, 2005·International Journal of Experimental Pathology·James R TurkM Harold Laughlin
Dec 21, 2010·Thrombosis Research·Khedar S RamcharanAndrew D Blann
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·X L WangD E Wilcken
Jan 16, 2009·Scandinavian Journal of Immunology·M A KhanK Alam
Nov 18, 2003·Journal of Applied Physiology·Mark A ThompsonM Harold Laughlin
Nov 25, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Sailesh C Harwani

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