Nitric oxide in human skin: current status and future prospects

The Journal of Investigative Dermatology
D Bruch-GerharzV Kolb-Bachofen

Abstract

The gaseous free radical nitric oxide is an important biologic mediator with physiologic and pathophysiologic roles in nearly every organ system. Because of its unique biologic activity, unusual chemical structure, and unprecedented mechanisms of action, nitric oxide, arguably more than any other natural product, has opened new avenues to investigate cellular processes. Nitric oxide is generated in biologic tissues by specific nitric oxide synthases that metabolize arginine and molecular oxygen to citrulline and nitric oxide. Besides its function as a diffusible messenger in the vasculature and in neurons, nitric oxide also plays a key role in innate immunity and inflammation. Recent progress has allowed the identification of the nitric oxide pathway in several cell types that reside in the skin, including keratinocytes, melanocytes, Langerhans cells, fibroblasts, and endothelial cells. Convincing evidence suggests that nitric oxide synthesis in these cells can be modulated by calcium-mobilizing agonists as well as diverse inflammatory and immune stimuli, and thereby contributes to the pathogenesis of several human skin diseases. Characterization of these intrinsic and extrinsic regulatory stimuli of nitric oxide synthesis has ...Continue Reading

References

Dec 28, 1992·Science·E Culotta, D E Koshland
May 1, 1992·Immunology Today·H Kolb, V Kolb-Bachofen
Aug 1, 1992·The Journal of Experimental Medicine·H J ChoC Nathan
Sep 4, 1992·Cell·C J Lowenstein, S H Snyder
Dec 28, 1992·Science·D E Koshland
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T NguyenS R Tannenbaum
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M S MulliganP A Ward
Mar 1, 1991·Immunology Today·F Y Liew, F E Cox
Feb 15, 1991·Biochemical Pharmacology·L J Ignarro
Jun 1, 1991·The Journal of Cell Biology·C Nathan, M Sporn
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jan 1, 1994·Medicinal Research Reviews·J F Kerwin, M Heller
Mar 1, 1994·The Biochemical Journal·R G Knowles, S Moncada
Sep 23, 1994·Cell·C Nathan, Q W Xie
Nov 21, 1994·FEBS Letters·U K MessmerB Brüne
Nov 1, 1994·Journal of Leukocyte Biology·Q Xie, C Nathan
Apr 1, 1995·Annals of Surgery·T R Billiar
Jan 1, 1995·Annual Review of Physiology·O W Griffith, D J Stuehr
Oct 1, 1995·Immunology Today·G WeissD Fuchs
Dec 1, 1994·British Journal of Plastic Surgery·G Burnstock, V Ralevic
Jan 1, 1995·Trends in Pharmacological Sciences·A R ButlerD L Williams
May 14, 1994·Lancet·E Anggård
Sep 23, 1994·Cell·H H Schmidt, U Walter
Jan 1, 1996·The Journal of Investigative Dermatology·P C GoldsmithJ C Foreman
Mar 27, 1996·Biochemical and Biophysical Research Communications·I AranyS K Tyring
Apr 1, 1996·The Journal of Investigative Dermatology·H A BullP M Dowd
Mar 1, 1996·The Journal of Investigative Dermatology·J E Baudouin, P Tachon
Apr 1, 1996·The Journal of Experimental Medicine·S StengerC Bogdan

❮ Previous
Next ❯

Citations

Dec 12, 2001·The British Journal of Dermatology·T SchönS Britton
Nov 17, 1999·Clinical and Experimental Dermatology·R Weller
Mar 11, 2010·European Heart Journal·Martin FeelischRichard B Weller
Feb 6, 2004·Clinical and Experimental Pharmacology & Physiology·Gursev S Dhaunsi, Pinar T Ozand
Jan 7, 1999·Pigment Cell Research·A J Thody, A Graham
May 13, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Dean L KelloggYubo Wu
Aug 19, 2011·BMC Gastroenterology·Renata Fc LeitãoRonaldo A Ribeiro
Apr 6, 2006·The AAPS Journal·Sanjoy Roychowdhury, Craig K Svensson
Jun 3, 2005·Biological & Pharmaceutical Bulletin·Sung-Sook WeeDong-Hyun Kim
May 3, 2006·Biological & Pharmaceutical Bulletin·Hyun LimHyun Pyo Kim
Jun 5, 2010·PLoS Genetics·Elke GrönnigerFrank Lyko
Jan 22, 2013·International Journal of Molecular Sciences·Katie M DixonRebecca S Mason
Jul 10, 2002·Experimental Dermatology·László VirágCsaba Szabó
Oct 5, 2002·Oral Diseases·A C BatistaV S Lara
Jan 25, 2011·Journal of Chemical Neuroanatomy·Therese S AbrahamSheng-Xing Ma
Nov 3, 2009·Nitric Oxide : Biology and Chemistry·Christoph V SuschekErnst E van Faassen
Oct 9, 2009·The Journal of Investigative Dermatology·Maria Francisca Garcia-SauraMartin Feelisch
Dec 16, 2006·The Journal of Investigative Dermatology·Ritu GuptaRebecca S Mason
Feb 26, 2000·The Journal of Investigative Dermatology·M TsatmaliA J Thody
Aug 21, 2001·The Journal of Investigative Dermatology·G SzolnokyL Kemény
Jan 5, 2000·The Journal of Investigative Dermatology·L H LernerE A Lerner
Oct 28, 2008·The Journal of Surgical Research·Pornprom MuangmanNicole S Gibran
Apr 1, 2008·The Journal of Surgical Research·Thaís P AmadeuAndréa Monte-Alto-Costa
Jul 3, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meital PortugalRon Kohen
Jul 31, 2007·Dermatologic Clinics·James J Nordlund
Aug 1, 2007·Free Radical Biology & Medicine·Christian OpländerChristoph V Suschek
Jul 13, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hosur N AchuthWalter Tiang Lee Tan

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