PMID: 7546625Jun 1, 1995Paper

Nitric oxide in hypertension and renal diseases

Annals of Medicine
I Tikkanen, F Fyhrquist

Abstract

Nitric oxide (NO) is intimately involved in the regulation of vascular tone, renal haemodynamics and sodium balance. The physiological actions of NO suggest important vascular and renal protective roles for NO. When produced in large amounts, however, NO may also mediate cytotoxic effects. Increasing evidence suggests that endothelial function, notably the NO pathway, may be compromised in hypertension. It is not known, however, whether changes in endothelial function are primary or secondary to the development of hypertension. In renal diseases evidence for both excessive and deficient activity of NO pathway has been found. Increased glomerular production of NO via inducible NO synthase (NOS) with potential cytotoxic consequences has been demonstrated in experimental acute glomerulonephritis. On the other hand, indirect evidence obtained by means of NOS inhibitors point out to an important renoprotective role for NO in renal diseases. NO may counteract disease progression in renal diseases by preventing glomerular microthrombi, maintaining renal perfusion and medullary oxygenation, and via its anti-inflammatory/antiproliferative effects. However, these beneficial effects of NO may be compromised (endothelial and/or tubular dys...Continue Reading

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Citations

Jul 1, 1998·Clinical Biochemistry·G EllisS K Makela
May 17, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Seiji MaedaMitsuo Matsuda
Jun 12, 2003·Clinical and Experimental Hypertension : CHE·Ujendra KumarAnita Sidhu
Feb 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Suin YoonInho Jo
Sep 15, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Inho JoSangmee Ahn Jo
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·X L WangD E Wilcken
Oct 19, 2005·Nephron. Physiology·Joseph SatrianoKaren A Munger
Mar 22, 2000·Journal of Hypertension·R S DanzigerM F Leppert
Oct 31, 2012·Molecular Biology Reports·Annan Sudarsan Arun KumarChandrasekaran Adithan

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