Nitric oxide in occurrence, progress and therapy of lung Cancer: a systemic review and meta-analysis.

BMC Cancer
Hongbin ZhouSa Ye

Abstract

Nitric oxide (NO) plays an important role in lung cancer. However, the results of previous studies about NO in the occurrence, progress and therapy were not consistent. Therefore, we conducted a meta-analysis to evaluate the relationship between NO and lung cancer. We carried out comprehensive search in the databases, and collected related studies. The data of fraction of exhaled nitric oxide (FeNO) or blood NO in different populations (lung cancer patients and control subjects) and different time points (before therapy and after therapy) were extracted by two investigators. A random effect model was applied to analyze the differences of FeNO and blood NO in different populations and different time points. To further compare NO level of each subgroup with different pathological types and different stages, a network meta-analysis (NMA) was performed. Fifty studies including 2551 cases and 1691 controls were adopted in this meta-analysis. The FeNO (SMD 3.01, 95% CI 1.89-4.13, p < 0.00001) and blood NO (SMD 1.34, 95% CI 0.84-1.85, p < 0.00001) level in lung cancer patients was much higher than that in control subjects. NMA model indicated blood NO level in each cancer type except SCLC was higher than that in control patients. Ther...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jun 2, 2001·Japanese Journal of Clinical Oncology·M KoizumiT Inoue
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jun 11, 2005·American Journal of Respiratory and Critical Care Medicine·Fares A MasriKulwant S Aulak
May 19, 2006·The European Respiratory Journal·A R WewelO Holz
Aug 22, 2006·Clinical Biochemistry·Mukaddes ColakogullariAsuman Tokullugil
Jan 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hidir EsmeMehmet Unlu
Jul 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiang Ping ChanPaul S Thomas
Jul 17, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Meigui ZhouYixiang Duan
Jul 23, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth A GrimmSuhendan Ekmekcioglu
Jun 14, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jayaji M MoréMaximilian Diehn
Jul 30, 2014·Nitric Oxide : Biology and Chemistry·Anand Krishnan V IyerNeelam Azad
Mar 5, 2016·The Clinical Respiratory Journal·Peng-Fei LiuLi-Xin Xie
Feb 24, 2018·Current Medicinal Chemistry·Xianquan ZhanShehua Qian
Sep 15, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Zhiyu LuChao Cao
Feb 2, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Li ZhangXiaofeng Xu
Nov 7, 2019·International Journal of Chronic Obstructive Pulmonary Disease·Yuzo SuzukiTakafumi Suda
Jan 9, 2020·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Dec 11, 2020·Cancer Biology & Medicine·Dianqin SunWanqing Chen
Dec 17, 2020·Signal Transduction and Targeted Therapy·Min YuanQing Xu

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