Nitric oxide in the prelimbic medial prefrontal cortex is involved in the anxiogenic-like effect induced by acute restraint stress in rats

Neuroscience
Carla Vila-VerdeFrancisco S Guimarães

Abstract

Neurons containing the neuronal nitric oxide synthase (nNOS) enzyme are located in brain areas related to defensive behavior, such as the ventromedial prefrontal cortex (vMPFC). Rats exposed to a live predator (a cat) present anxiety-like behavior and an increased number of nNOS-positive neurons in this brain area one-week later. Moreover, stress-related behavioral changes in rodents can be prevented by systemic or local vMPFC nNOS inhibition. In the present study we investigated if acute restraint stress (RS)-induced delayed (one-week) anxiogenic-like effect was associated with increased nNOS expression or activity in the vMPFC. Furthermore, we also tested if local pharmacological nNOS inhibition would prevent stress-induced behavioral changes. Male Wistar rats were submitted to RS for 3h and tested in the elevated plus maze (EPM) 24h or 7 days later. Two hours after the EPM test, their brains were removed, processed and nNOS expression in the vMPFC was evaluated by immunohistochemistry. Another group of animals was used for measuring NO metabolites (NOx; an indirect measure of NOS activity) immediately after the EPM test, 24h after RS. Independent groups had guide cannula implanted bilaterally into the prelimbic (PL) portion ...Continue Reading

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Citations

Aug 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jie LiuJian-You Guo
Feb 23, 2020·The International Journal of Neuroscience·Rajdeep KaurAnjana Bali
Aug 3, 2019·Physiological Genomics·Pan XuHui Lu
Sep 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·ZhengLin ZhaoYiYan Wu
Mar 14, 2021·Pharmacological Reports : PR·Artur PałaszJohn J Worthington

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