Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus.

The European Journal of Neuroscience
Adam HockleyMark N Wallace

Abstract

Previous work has led to the hypothesis that, during the production of noise-induced tinnitus, higher levels of nitric oxide (NO), in the ventral cochlear nucleus (VCN), increase the gain applied to a reduced input from the cochlea. To test this hypothesis, we noise-exposed 26 guinea pigs, identified evidence of tinnitus in 12 of them and then compared the effects of an iontophoretically applied NO donor or production inhibitor on VCN single unit activity. We confirmed that the mean driven firing rate for the tinnitus and control groups was the same while it had fallen in the non-tinnitus group. By contrast, the mean spontaneous rate had increased for the tinnitus group relative to the control group, while it remained the same for the non-tinnitus group. A greater proportion of units responded to exogenously applied NO in the tinnitus (56%) and non-tinnitus groups (71%) than a control population (24%). In the tinnitus group, endogenous NO facilitated the driven firing rate in 37% (7/19) of neurons and appeared to bring the mean driven rate back up to control levels by a mechanism involving N-methyl-D-aspartic acid (NMDA) receptors. By contrast, in the non-tinnitus group, endogenous NO only facilitated the driven firing rate in ...Continue Reading

References

Jan 1, 1979·The Journal of the Acoustical Society of America·J R JohnstoneG K Yates
Apr 1, 1992·Neuron·O ManzoniL Fagni
Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Nov 1, 1988·Medical & Biological Engineering & Computing·D C BullockA Rees
Mar 1, 1994·The Biochemical Journal·R G Knowles, S Moncada
May 22, 1994·The Journal of Comparative Neurology·M WatanabeY Inoue
Nov 4, 1996·The Journal of Comparative Neurology·B R Schofield, N B Cant
Mar 16, 2001·Progress in Neurobiology·H Prast, A Philippu
Sep 5, 2003·Experimental Brain Research·A R PalmerT M Shackleton
Apr 14, 2004·The European Journal of Neuroscience·Rachel HopperJohn Garthwaite
Sep 11, 2004·Journal of the Association for Research in Otolaryngology : JARO·Robert H ArnottAlan R Palmer
Aug 12, 2005·Journal of Neurophysiology·Christian J SumnerSusan E Shore
Feb 24, 2006·Behavioral Neuroscience·Jeremy G TurnerDonald M Caspary
Nov 4, 2008·American Journal of Audiology·Jeremy G Turner, Jennifer Parrish
Dec 19, 2008·Journal of the Association for Research in Otolaryngology : JARO·Alan R Palmer, Trevor M Shackleton
Feb 19, 2009·Journal of Negative Results in Biomedicine·Birgit MazurekPhilipp P Caffier
Jun 10, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Diane T StephensonDaniel Morton
Aug 18, 2009·The Journal of Pharmacology and Experimental Therapeutics·Anbrin MasoodJames M O'Donnell
Jun 9, 2010·The European Journal of Neuroscience·Songyu DongDonald Robertson
Nov 26, 2010·Neuroscience and Biobehavioral Reviews·Arnaud Jean Noreña
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Darryl P VoglerWilhelmina H A M Mulders
Jun 15, 2011·Journal of the Association for Research in Otolaryngology : JARO·Ryan J Longenecker, Alexander V Galazyuk
Jun 21, 2011·Journal of the Association for Research in Otolaryngology : JARO·Harrison W LinM Charles Liberman
Jul 5, 2011·Nitric Oxide : Biology and Chemistry·Yara CurySergio Henrique Ferreira
Sep 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roland Schaette, David McAlpine
Feb 22, 2012·Hearing Research·Donald RobertsonWilhelmina H A M Mulders
Mar 22, 2012·Journal of Neuroscience Research·Jeremy TurnerSusan Shore
Jun 5, 2012·Nitric Oxide : Biology and Chemistry·Ulf-Rüdiger Heinrich, Kai Helling
Aug 8, 2012·Journal of the Association for Research in Otolaryngology : JARO·Jianwen Wendy GuJennifer R Melcher

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