PMID: 9648874Jul 2, 1998Paper

Nitric oxide-induced release of acetylcholine in the nucleus accumbens: role of cyclic GMP, glutamate, and GABA

Journal of Neurochemistry
H PrastA Philippu

Abstract

We have previously shown that the basal acetylcholine release in the ventral striatum is under the enhancing influence of endogenous nitric oxide (NO) and that NO donors cause pronounced increases in the acetylcholine release rate. To investigate the role of cyclic GMP, glutamate, and GABA in the NO-induced acetylcholine release, we superfused the nucleus accumbens, (Nac) of the anesthetized rat with various compounds through a push-pull cannula and determined the neurotransmitter released in the perfusate. Superfusion of the Nac with the NO donors diethylamine/NO (DEANO; 100 micromol/L), S-nitroso-N-acetylpenicillamine (SNAP; 200 micromol/L), or 3-morpholinosydnonimine (SIN-1; 200 micromol/L) enhanced the acetylcholine release rate. The guanylyl cyclase inhibitor 1H-(1,2,4)-oxodiazolo(4,3-a)quinoxalin-1-one (ODQ; 10 micromol/L) abolished the effects of DEANO and SIN-1. 6-(Phenylamino)-5,8-quinolinedione (LY-83583; 100 micromol/L), which also inhibits cyclic GMP synthesis, inhibited the releasing effects of DEANO and of SNAP, whereas the effect of SIN-1 on acetylcholine release was not influenced. The DEANO-induced release of acetylcholine was also abolished in the presence of 20 micromol/L 6,6-dinitroquinoxaline-2,3-dione (DNQ...Continue Reading

Citations

Oct 25, 2007·Biochemical Society Transactions·O PierreficheJ F R Paton
Aug 7, 2009·Fundamental & Clinical Pharmacology·Baljinder KaurAmteshwar Singh Jaggi
May 25, 2010·Journal of Neurochemistry·Ximena Corso-Díaz, Teresa L Krukoff
Dec 18, 2001·Journal of Neuroscience Research·A Szutowicz
Sep 22, 2006·The European Journal of Neuroscience·A V KalinchukT Porkka-Heiskanen
Nov 22, 2013·Journal of Neurophysiology·Joshua D FosterGareth B Miles
Oct 2, 2002·Journal of Neurochemistry·Marie-Luise Buchholzer, Jochen Klein
Jul 29, 2008·Psychopharmacology·Andrey KostinTarja Porkka-Heiskanen
Apr 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Henrike HartungStephanie J Cragg
Sep 21, 2007·Nature Reviews. Neuroscience·Vittorio CalabreseAnna Maria Giuffrida Stella
Jun 8, 2007·The European Journal of Neuroscience·Elisabet Reyes-IrisarriJan de Vente
Oct 15, 2010·The International Journal of Neuroscience·Behnam SabayanBehrang Sabayan
Jul 16, 2003·Sleep & Breathing = Schlaf & Atmung·James S J Haight, Per Gisle Djupesland
Aug 24, 2005·Progress in Neurobiology·F X GuixF J Muñoz
Aug 18, 2004·Neurochemistry International·Jan de Vente
Dec 27, 2005·Progress in Neurobiology·Julie Y H ChanSamuel H H Chan

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