PMID: 8971733Dec 1, 1996Paper

Nitric oxide influences the release of histamine and glutamate in the rat hypothalamus

Naunyn-Schmiedeberg's Archives of Pharmacology
H PrastA Philippu

Abstract

To investigate the influence of nitric oxide (NO) on the release of histamine and glutamate, the anterior hypothalamus of anaesthetized rats was superfused through a push-pull cannula either with artificial cerebrospinal fluid (CSF) or with various drugs dissolved in CSF. Hypothalamic superfusion with the NO-donating compounds linsidomine (200 mumol/l) or diethylamine-NO (DEANO, 100 mumol/l) led to a pronounced and sustained decrease in the histamine release rate, whereas the release rate of glutamate was enhanced. Superfusion with the inhibitor of NO synthase L-NG-nitro-L-arginine methyl ester (L-NAME, 200 mumol/l) increased the histamine release rate. The inhibitory effect of 200 mumol/l linsidomine was abolished by atropine (10 mumol/l). Superfusion with the glutamate receptor agonists glutamate (100 mumol/l) or N-methyl-D-aspartate (NMDA, 50 mumol/l) enhanced the histamine release rate. In the presence of linsidomine, the releasing effect of NMDA was not changed. These findings demonstrate that the release of histamine in the hypothalamus is diminished by endogenous NO. This effect of NO on histamine release seems to be due to enhanced release of acetylcholine from vicinal cholinergic neurons via stimulation of muscarinic a...Continue Reading

References

Apr 1, 1992·Neuron·O ManzoniL Fagni
Mar 24, 1992·European Journal of Pharmacology·K OkakuraH Wada
May 27, 1992·European Journal of Pharmacology·H Prast, A Philippu
Sep 22, 1992·European Journal of Pharmacology·G LonartK M Johnson
Feb 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·T MochizukiH Wada
Aug 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·H PrastA Philippu
Jan 1, 1989·Neuroscience·P PanulaM S Airaksinen
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jul 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·H PrastA Philippu
Mar 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·H PrastA Philippu
Feb 1, 1994·Journal of Neurochemistry·R Guevara-GuzmanK M Kendrick
Oct 1, 1953·Journal of Neuropathology and Experimental Neurology·H KLUVER, E BARRERA

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Citations

Jul 29, 2008·Psychopharmacology·Andrey KostinTarja Porkka-Heiskanen
Jul 23, 1999·Brain Research·S T KaehlerA Philippu
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Fabrício de Araújo MoreiraFrancisco Silveira Guimarães
Oct 20, 2001·Behavioural Brain Research·A Philippu, H Prast
Feb 13, 2001·Progress in Neurobiology·R E BrownH L Haas
Mar 16, 2001·Progress in Neurobiology·H Prast, A Philippu
Oct 7, 1998·Progress in Neurobiology·N Singewald, A Philippu
Aug 24, 2005·Progress in Neurobiology·F X GuixF J Muñoz
Sep 3, 2005·Neurobiology of Disease·Minnamaija LintunenPertti Panula
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kun ZhangKaushik P Patel
Apr 3, 2021·Scientific Reports·Eva Ramos-FernándezNibaldo C Inestrosa

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