PMID: 15228083Jul 2, 2004Paper

Nitric oxide inhibition decreases bleomycin-detectable iron in spleen, bone marrow cells and heart but not in liver in exercise rats

Molecular and Cellular Biochemistry
De-Sheng XiaoZhong Ming Qian

Abstract

The possible role of nitric oxide on the exercise-induced changes in bleomycin-detectable iron (BDI) in the liver, spleen, bone marrow cells and heart was investigated. Female Sprague-Dawley rats were randomly assigned to four groups: S1 (Sedentary), S2 (Sedentary + L-NAME [N-nitro-L-arginine methyl ester]), E1 (Exercise) and E2 (Exercise + L-NAME). Animals in the E1 and E2 swam for 2 h/day for 3 months. L-NAME in the drinking water (1 mg/ml) was administrated to rats in the S2 and E2 groups for the same period. At the end of the 3rd month, nitrite and nitrate (NOx), BDI and non-heme iron (NHI) contents in the liver, spleen, bone marrow cells and heart were measured. The ratio of BDI/NHI was calculated. The exercise induced a significant increase in NOx and BDI contents and/or BDI/NHI ratio in the spleen, bone morrow cells and heart. Treatment with L-NAME, an inhibitor of NOS, led to a significant decrease in NOx and an increase in BDI levels and BDI/NHI ratios in these tissues. The correlative analysis showed that there is significantly positive correlation between NOx levels and BDI contents and/or BDI/NHI ratios in the spleen, bone marrow cells and heart. These results suggest that the increased nitric oxide might be one of ...Continue Reading

Citations

Jun 30, 2012·Phytotherapy Research : PTR·Muaz BelviranlıSadık Büyükbaş
Sep 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yu-Fu ZhouYa Ke
Dec 22, 2010·Biological Trace Element Research·Li-Long CheLiwei Lu
Mar 25, 2017·Journal of Cellular Physiology·Qian-Qian LuoZhong-Ming Qian
Dec 15, 2017·Annals of Nutrition & Metabolism·Qian-Qian LuoZhong-Ming Qian
Dec 1, 2005·Molecular and Cellular Biochemistry·Yu Qian LiuZhong Ming Qian
Nov 26, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Andrew J GhioUrmila P Kodavanti

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