PMID: 9426020Jan 13, 1998Paper

Nitric oxide inhibition impairs blood flow during exercise in hearts with a collateral-dependent myocardial region

Journal of the American College of Cardiology
J H TraverseRobert J Bache

Abstract

We sought to determine the importance of nitric oxide (NO) production in maintaining coronary blood flow during exercise in hearts with collateral-dependent myocardium. Coronary collateral vessels demonstrate endothelium-mediated NO-dependent vasodilation in response to agonists such as acetylcholine. However, the contribution of endogenous NO production to maintaining vasodilation of coronary collateral vessels during exercise has not been previously studied. Collateral vessel growth was induced in 13 chronically instrumented dogs by intermittent 2-min occlusions, followed by permanent occlusion of the left anterior descending coronary artery (LAD). One week after permanent LAD occlusion, myocardial blood flow was measured with microspheres during rest and treadmill exercise at 6.4 km/h at a 15% grade. Measurements were then repeated after blockade of NO production with N-nitro-L-arginine (LNNA) (20 mg/kg body weight intravenously). LNNA caused a 62 +/- 4% (mean +/- SEM) inhibition of the coronary vasodilation produced by acetylcholine. During rest conditions, LNNA caused a slight decrease in blood flow to the collateral region (p = NS), with no change in normal zone blood flow. During exercise, LNNA caused a decrease in mean ...Continue Reading

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Citations

Feb 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Juan Carlos RoblesCristine L Heaps
Apr 2, 2009·Environmental Health Perspectives·Carlo R BartoliJohn J Godleski
Sep 16, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Juan Carlos Robles, Cristine L Heaps
Sep 26, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Wei XieCristine L Heaps
Aug 28, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Juliane C CamposJulio C B Ferreira
Nov 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Ali A YoussefHon-Kan Yip
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
Jul 13, 2000·Journal of Cardiovascular Pharmacology·C L Klassen, R J Bache
Jun 26, 1998·Journal of Cardiovascular Pharmacology·B B QuebbemannR J Bache
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J R KerstenD C Warltier
Nov 24, 1999·Journal of Applied Physiology·K L GriffinJ L Parker
Dec 11, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Yingjie ChenRobert J Bache
Aug 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Cristine L HeapsJanet L Parker
Aug 10, 2021·International Journal of Cardiology·Jay H Traverse

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