PMID: 9444985Jan 28, 1998Paper

Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line

Journal of Virology
S P SandersDavid Proud

Abstract

To better understand the early biochemical events that occur in human rhinovirus (HRV) infections, we examined the kinetics and mechanisms of interleukin-8 (IL-8) and IL-6 production from infected epithelial cells. Several HRV strains caused IL-8 and IL-6 production, but HRV-16 induced maximal IL-8 and IL-6 mRNA expression and protein production more rapidly than did HRV-14, despite similar rates of replication of the two viral strains. Viral induction of cytokine mRNA does not require new protein synthesis, since it was unaffected by cycloheximide treatment. The potent glucocorticoid budesonide did not affect viral replication or cytokine mRNA induction but modestly inhibited cytokine protein production. Interestingly, the nitric oxide donor 3-(2-hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine (NONOate) inhibited both rhinovirus replication and cytokine production in a dose-dependent fashion without reducing levels of cytokine mRNA. The NONOate effects were due to release of nitric oxide, because NONOate that had been depleted of its nitric oxide content had no effect. Thus, nitric oxide may play an important anti-inflammatory and antiviral role in colds and nitric oxide donors may represent a novel therapeutic approach.

References

Sep 11, 1992·The Journal of Allergy and Clinical Immunology·B W TurnerJ M Gwaltney
Apr 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R D CurranT R Billiar
Jun 1, 1990·The Annals of Otology, Rhinology, and Laryngology·M ArolaO Ruuskanen
Jan 1, 1990·The Journal of Infectious Diseases·D ProudJ O Hendley
Jan 1, 1988·The Journal of Infectious Diseases·R M NaclerioJ M Gwaltney
Aug 1, 1989·The American Review of Respiratory Disease·L ChurchillD Proud
Oct 1, 1989·The Journal of Clinical Investigation·M BaggioliniS L Kunkel
Aug 1, 1988·Journal of Medical Virology·R A LevandowskiG G Jackson
Dec 8, 1966·The New England Journal of Medicine·J M GwaltneyW S Jordan
Jun 1, 1982·The Journal of Infectious Diseases·R B TurnerJ M Gwaltney
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jul 1, 1980·British Journal of Diseases of the Chest·V U McHardyR W Riddell
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·K AsanoJ S Stamler
Apr 1, 1995·Journal of Virology·Z Bi, C S Reiss
Feb 1, 1995·The European Respiratory Journal·S A KharitonovP J Barnes
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·T C SimR Alam
May 13, 1995·BMJ : British Medical Journal·S L JohnstonD A Tyrrell
Feb 1, 1994·American Journal of Respiratory Cell and Molecular Biology·P G BardinS T Holgate
Oct 16, 1993·BMJ : British Medical Journal·K G NicholsonD C Ireland
Jan 6, 1994·The New England Journal of Medicine·J M GwaltneyD K Riker
Jan 1, 1996·The Journal of Allergy and Clinical Immunology·L M SchwiebertL A Schwiebert
Apr 15, 1996·The Journal of Clinical Investigation·C J LowensteinA Herskowitz
Apr 1, 1996·The Journal of Allergy and Clinical Immunology·L M GustafsonJ M Gwaltney
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·S L JohnstonS T Holgate
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·S MatsukuraM Adachi

❮ Previous
Next ❯

Citations

Nov 20, 1998·Allergy·S L Johnston
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·P KaulR B Turner
Dec 23, 1999·Current Opinion in Pulmonary Medicine·R S Peebles, T V Hartert
Mar 14, 2001·American Journal of Respiratory Cell and Molecular Biology·S P SandersD Proud
Feb 4, 2003·Current Allergy and Asthma Reports·Nikolaos G Papadopoulos, Stelios Psarras
May 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Philomena M Kaan, Richard G Hegele
Nov 11, 2003·American Journal of Respiratory and Critical Care Medicine·Sebastian L Johnston
Apr 27, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shuo ZhengSerpil C Erzurum
Feb 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M ContoliA Papi
Jan 12, 2005·Current Opinion in Allergy and Clinical Immunology·David Proud
Mar 15, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jason C L SpurrellDavid Proud
May 9, 2006·Allergy·P W Hellings, W J Fokkens
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine LauChung-Wai Chow
Jan 15, 2011·Clinical Microbiology Reviews·Marjolaine VareilleNicolas Regamey
Aug 9, 2013·American Journal of Respiratory and Critical Care Medicine·Matthew G DrakeElad H Kaufman
May 29, 2016·Archives of Virology·Mohamed Sarjoon Abdul-CaderMohamed Faizal Abdul-Careem
Nov 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T OdaN Mukaida
Oct 26, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J B MannickR W Finberg
Jul 31, 2003·American Journal of Respiratory and Critical Care Medicine·Jean-Jacques Rouby
Jun 17, 2006·American Journal of Respiratory Cell and Molecular Biology·David Proud, Chung-Wai Chow
Sep 16, 2003·Journal of Leukocyte Biology·Simon D Message, Sebastian L Johnston
Sep 29, 2009·American Journal of Respiratory Cell and Molecular Biology·Claire E TaconRichard Leigh
Jul 29, 2008·American Journal of Respiratory and Critical Care Medicine·David ProudJeffrey W Clymer
Jan 13, 2012·American Journal of Reproductive Immunology : AJRI·Jennifer Claire PriceIain Martin Sheldon
Mar 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire E TaconRichard Leigh
Aug 8, 2014·Journal of Virology·Aurelie MousnierRoberto Solari
Jul 14, 2019·Respiratory Research·Stephanie M WarnerDavid Proud
Apr 2, 2020·Frontiers in Cellular and Infection Microbiology·Kyla C JamiesonDavid Proud
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J KimD Proud
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S D GriegoS B Dillon
Mar 26, 2002·Nature Reviews. Immunology·James E Gern, William W Busse
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·James E GernWilliam W Busse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
J KimDavid Proud
Proceedings of the Society for Experimental Biology and Medicine
S P Sanders
© 2021 Meta ULC. All rights reserved