PMID: 8968182Dec 1, 1996Paper

Nitric oxide involvement in hypoxic dilation of pial arteries in the cat

Anesthesiology
N IshimuraH Furuya

Abstract

The reactivity of cerebral arteries to different stimuli varies according to vessel size. Whether nitric oxide mediates hypoxic vasodilation is controversial. The authors considered this question by measuring the diameter of pial arteries and arterioles with or without exposure to the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME). The cranial window technique, combined with microscopic video recording, was used in an experiment involving 20 cats anesthetized with fentanyl and midazolam. The diameters of pial arteries and arterioles were measured under the following conditions: (1) normoxia (PaO2 > 100 mmHg); (2) hypoxia (PaO2 < 45 mmHg); (3) normoxia with L-NAME infusion; and (4) hypoxia with L-NAME infusion. Changes in vessel diameter were analyzed with respect to artery size. Under hypoxic conditions, arteries and arterioles smaller than 200 microns were dilated significantly (P < 0.05). In arterioles smaller than 200 microns, L-NAME attenuated this hypoxic vasodilation (P < 0.05). In contrast, under normoxic conditions, L-NAME caused significant vasoconstriction in arteries larger than 100 microns but not in arteries smaller than 100 microns. Arteries and arterioles smaller than 200 microns ...Continue Reading

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Citations

Feb 28, 2002·British Journal of Pharmacology·C GuibertD J Beech
Sep 14, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·R AfshariD N Bateman
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Oct 20, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kazuto Masamoto, Alberto Vazquez
Apr 8, 1998·The American Journal of Physiology·A G HudetzJ P Kampine
Feb 14, 2002·Journal of Applied Physiology·Annette H M Van MilGerard J Blauw
Oct 24, 2002·The Journal of Trauma·Satoki InoueHitoshi Furuya

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