PMID: 12620706Mar 7, 2003Paper

Nitric oxide is a determinant of membrane fluidity of erythrocytes in postmenopausal women: an electron paramagnetic resonance investigation

American Journal of Hypertension
K TsudaI Nishio

Abstract

In the present study, to determine a possible role of nitric oxide (NO) in the regulation of membrane functions, we examined the relationship between plasma NO level and membrane fluidity of erythrocytes in postmenopausal women. We evaluated the membrane fluidity of erythrocytes obtained from hypertensive and normotensive postmenopausal women by means of an electron paramagnetic resonance (EPR) and spin labeling method. The EPR study revealed that the order parameter (S) for 5-nitroxide stearate in erythrocyte membranes was significantly greater in hypertensive postmenopausal women than in normotensive postmenopausal women. The finding indicated that the membrane fluidity of erythrocytes was decreased in hypertensive postmenopausal women compared with normotensive postmenopausal women. The plasma level of the NO metabolites (nitrite and nitrate) while fasting was significantly lower in hypertensive postmenopausal women than in normotensive postmenopausal women. In addition, the order parameter (S) in the EPR spectra of erythrocyte membranes was inversely correlated with the plasma NO metabolite level, which indicated that the lower membrane fluidity of erythrocytes was associated with the lower plasma NO level in postmenopausal...Continue Reading

Citations

Jun 9, 2004·Circulation·Kazushi Tsuda, Ichiro Nishio
Jan 5, 2010·Molecular and Cellular Biochemistry·Paramahamsa MaturuVaradacharyulu Nallanchakravarthula
Feb 7, 2017·Journal of Clinical Biochemistry and Nutrition·Saradamma BulleVaradacharyulu Nallanchakravarthula
Sep 2, 2004·Obesity Research·Kazushi Tsuda, Ichiro Nishio
Dec 18, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Joanna BrzeszczynskaAnna Jegier
Nov 6, 2007·Cell Biology International·Joanna Brzeszczynska, Krzysztof Gwozdzinski

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