PMID: 7538702May 1, 1994Paper

Nitric oxide is a key molecule in migraine and other vascular headaches

Trends in Pharmacological Sciences
J OlesenH K Iversen

Abstract

Nitric oxide (NO) may play a key role in migraine and other vascular headaches since glyceryl trinitrate (a donor of NO) and histamine (which probably activates endothelial NO formation) both cause a pulsating dose-dependent headache with several migrainous characteristics. At relatively high doses of glyceryl trinitrate, migraine sufferers develop stronger and more migraine-like headaches and more pronounced cerebral arterial dilatation than controls. After the infusion of glyceryl trinitrate, non-migraineurs remain headache-free while migraineurs develop a migraine-like attack. In this review, Jes Olesen, Lars Thomsen and Helle Iversen suggest that migraine may be caused by increased amounts and/or affinity of an enzyme in the NO-triggered cascade of reactions. NO may also be involved in the pathogenesis of other vascular headaches.

References

Dec 28, 1992·Science·E Culotta, D E Koshland
Sep 1, 1992·Annals of Neurology·T M DawsonS H Snyder
Sep 1, 1991·Cephalalgia : an International Journal of Headache·A L OttossonL Edvinsson
Oct 6, 1990·Lancet·H K IversenP Tfelt-Hansen
Apr 1, 1990·Cephalalgia : an International Journal of Headache·A DahlK Rootwelt
Apr 1, 1990·Stroke; a Journal of Cerebral Circulation·F T NicholsW J Michelsen
Feb 1, 1989·Stroke; a Journal of Cerebral Circulation·P Scheinberg
Apr 1, 1987·Headache·F SicuteriA Bonazzi
Nov 30, 1988·Biochemical and Biophysical Research Communications·J B HibbsE M Rachlin
Mar 1, 1988·Cephalalgia : an International Journal of Headache·F SorgeP Carrieri
Mar 1, 1984·Cephalalgia : an International Journal of Headache·A A KrabbeJ Olesen
Jun 1, 1982·Archives of Neurology·R C Peatfield
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K NozakiS H Snyder
Dec 1, 1993·Cephalalgia : an International Journal of Headache·L L ThomsenJ Olesen
Feb 1, 1993·Pain·S T Meller, G F Gebhart

❮ Previous
Next ❯

Citations

Aug 5, 1998·International Journal of Clinical & Laboratory Research·P MartellettiM Giacovazzo
Mar 20, 2012·Journal of Neural Transmission·Alexander Mauskop, Jasmine Varughese
Jul 17, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fabio FredianiGerardo Casucci
Jun 1, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G CasucciF D'Onofrio
May 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Abraham J Nagy, Alan M Rapoport
Nov 27, 2010·Current Treatment Options in Neurology·Teshamae S Monteith, Peter J Goadsby
Nov 18, 2011·Current Treatment Options in Neurology·Jan Hoffmann, Peter J Goadsby
Jun 18, 2005·Brain Research. Brain Research Reviews·Theoharis C TheoharidesAphrodite Konstantinidou
May 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lars Edvinsson, Tony W Ho
May 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jes Olesen
Nov 12, 2002·Brain Research·Simon AkermanPeter J Goadsby
Apr 9, 2002·European Journal of Pharmacology·José A Terrón
Oct 2, 2002·European Journal of Pharmacology·Simon AkermanPeter J Goadsby
Jun 18, 1997·European Journal of Pharmacology·K AyajikiN Toda
Aug 12, 1999·European Journal of Pharmacology·P De VriesP R Saxena
Aug 23, 2002·Pharmacology & Therapeutics·Paul L Durham, Andrew F Russo
Dec 26, 2001·Brain Research. Brain Research Reviews·A Gorji
Feb 20, 1999·Neuroscience Letters·E Knyihár-Csillik, L Vécsei
Aug 5, 1999·Experimental Gerontology·H GlossmannG Bartsch
Jul 13, 1999·British Journal of Pharmacology·J A Terrón, A Falcón-Neri
Apr 1, 2000·British Journal of Pharmacology·K MesslingerR F Schmidt
Jan 13, 2001·British Journal of Pharmacology·D Martens, G Kojda
Aug 29, 2000·Cephalalgia : an International Journal of Headache·G StirparoP Martelletti
Aug 29, 2000·Cephalalgia : an International Journal of Headache·A CostaG Nappi
Oct 19, 2000·Cephalalgia : an International Journal of Headache·I ChristiansenJ Olesen
Nov 8, 2002·Cephalalgia : an International Journal of Headache·C SjöstrandJ Hillert
Jan 22, 2003·Cephalalgia : an International Journal of Headache·I CiancarelliA Carolei
Feb 27, 2003·Cephalalgia : an International Journal of Headache·J N de HoonL M van Bortel
Jun 17, 2003·Cephalalgia : an International Journal of Headache·A CostaG Nappi
Jun 17, 2003·Cephalalgia : an International Journal of Headache·M Empl, G Giovannoni
Sep 7, 2013·Critical Reviews in Food Science and Nutrition·Mayur VirarkarAtif B Awad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.