PMID: 8959032Oct 31, 1996Paper

Nitric oxide is a mediator of methamphetamine (METH)-induced neurotoxicity. In vitro evidence from primary cultures of mesencephalic cells

Annals of the New York Academy of Sciences
P ShengJ L Cadet

Abstract

METH is a monoaminergic toxic that destroys dopamine terminals in vivo. Oxidative mechanisms associated with DA metabolism are thought to play an important role in its toxic effects. These ideas were supported by the demonstration that CuZn-superoxide dismutase (CuZnSOD) transgenic mice were protected against the toxic effects of the drug. In the present study, we sought to determine if nitric oxide (NO) production was also involved in METH-induced neurotoxicity using primary cultures obtained from fetal rat mesencephalon. METH caused dose- and time-dependent cell death in vitro. Blockade of nitric oxide (NO) formation with several nitric oxide (NO) synthase blockers attenuated METH-mediated toxicity. Moreover, inhibition of ADP-ribosylation with nicotinamide and benzamide also provided protection against the toxicity of the drug. These results, together with our previous results in transgenic mice, support a role for free radicals in METH-induced toxic effects.

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Citations

Apr 24, 2007·Neurotoxicity Research·Jean Lud CadetJohnalyn Lyles
Dec 3, 2003·Brain Research. Developmental Brain Research·Patricia TagliaferroAlicia Brusco
Dec 13, 2000·Brain Research. Brain Research Reviews·D O Frost, J L Cadet
Aug 23, 2001·Brain Research. Brain Research Reviews·C DavidsonE H Ellinwood
Mar 31, 2009·Brain Research Reviews·Irina N Krasnova, Jean Lud Cadet
Oct 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean Lud CadetXiaolin Deng
Dec 16, 2003·Environmental and Molecular Mutagenesis·Jih-Heng LiShih-Ku Lin
Apr 19, 2002·Molecular Pharmacology·Subramaniam JayanthiJean Lud Cadet
Nov 21, 2000·Annals of the New York Academy of Sciences·J L Cadet, S Ordonez
Jul 10, 2002·Annals of the New York Academy of Sciences·Cristina PrudêncioMaria Amélia Tavares
Aug 13, 1999·Journal of Enzyme Inhibition·M Banasik, K Ueda
Sep 19, 2021·The Journal of Pharmacology and Experimental Therapeutics·Douglas R MillerHabibeh Khoshbouei

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