PMID: 8594919Dec 1, 1995Paper

Nitric oxide is an important determinant of coronary flow at rest and during hypoxemic stress in fetal lambs

The American Journal of Physiology
M D RellerK L Thornburg

Abstract

Fourteen fetal lambs were instrumented with atrial, coronary sinus, and arterial catheters and a proximal left circumflex coronary artery Doppler probe and were studied at a mean gestational age of 130 +/- 3 (SD) days, 7 +/- 2 days after surgery. Myocardial blood flow was assessed using 15-microns microspheres and Doppler flow velocities. In 11 fetuses, the maximal myocardial flow response to left atrial adenosine infusion was 802 +/- 215 ml.min-1 x 100 g-1, 3.5-fold greater than baseline flow. Acute fetal hypoxemia in six fetuses to an arterial PO2 of 8.8 +/- 0.8 mmHg and an arterial O2 content (CaO2) of 1.7 +/- 0.2 ml/dl was not associated with significant change in coronary perfusion pressure; yet left ventricular myocardial flow increased to 1,020 +/- 198 ml.min-1 x 100 g-1, a value significantly greater than that seen with adenosine (P < 0.05). Left atrial N omega-nitro-L-arginine (L-NNA), a competitive inhibitor of nitric oxide synthase (NOS), was infused at a dosage of approximately 1 mg.kg-1.min-1 for 60 min in 10 fetuses. Although L-NNA was associated with a significant increase in arterial pressure, left ventricular myocardial flow decreased (162 +/- 79 ml.min-1 x 100 g-1) as did myocardial O2 consumption (P < 0.05). ...Continue Reading

Citations

Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Srinath SettyH Fred Downey
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K RuijtenbeekJ G R De Mey
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A P HarrisR C Koehler
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S SettyH F Downey
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A L MulderC E Blanco
May 21, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Emilia M SanhuezaAníbal J Llanos
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D WotheL Davis
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A L M MulderC E Blanco
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L P ThompsonC P Weiner
Nov 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Arlin B BloodGordon G Power
Jun 29, 2005·Journal of the Society for Gynecologic Investigation·Loren P Thompson, Yafeng Dong
Sep 20, 2018·Journal of Perinatal Medicine·Percy PacoraNicholas Kadar

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