PMID: 7544743Aug 21, 1995Paper

Nitric oxide is involved in heat-induced HSP70 accumulation

FEBS Letters
Malyshev IYuA F Vanin

Abstract

Heat shock potentiated the nitric oxide production (EPR assay) in the liver, kidney, heart, spleen, intestine, and brain. The heat shock-induced sharp transient increase in the rate of nitric oxide production preceded the accumulation of heat shock proteins (HSP70) (Western blot analysis) as measured in the heart and liver. In all organs the nitric oxide formation was completely blocked by the NO-synthase inhibitor N omega-nitro-L-arginine (L-NNA). L-NNA also markedly attenuated the heat shock-induced accumulation of HSP70. The results suggests that nitric oxide is involved in the heat shock-induced activation of HSP70 synthesis.

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Citations

Jan 23, 1999·The Journal of Biological Chemistry·M ZhongC Wu
May 2, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Adam SteensbergMikael Sander
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