PMID: 7542243Apr 1, 1995Paper

Nitric oxide is involved in non-adrenergic, non-cholinergic inhibitory neurotransmission in rat duodenum

Journal of Autonomic Pharmacology
A PostorinoF Mulè

Abstract

1. In rat duodenum, electrical field stimulation (EFS) induced a relaxation due to activation of non-adrenergic, non-cholinergic (NANC) inhibitory intramural neurones. 2. Nitric oxide synthase (NOS) inhibitors, N omega-nitro-L-arginine (L-NNA) and N omega-nitro-L-arginine methyl ester (L-NAME), caused a dose-dependent reduction in amplitude of the NANC relaxation. Responses to low frequencies of stimulation were more sensitive to NOS inhibitors than those to high frequencies. 3. Effects induced by NOS inhibitors were stereospecific since D-NNA and D-NAME did not affect NANC relaxation. L-arginine, but not D-arginine, partially prevented the effects induced by NOS inhibitors on NANC relaxation. 4. The nitrovasodilator drug, sodium nitroprusside, caused muscle relaxation which was not affected by preincubation with either tetrodotoxin (TTX), L-NNA or L-NAME. 5. alpha-Chymotrypsin reduced relaxations elicited by stimulation of NANC nerves, especially when high frequencies of stimulation were used. The residual NANC relaxation was further reduced by NOS inhibitors. In the same way, alpha-chymotrypsin was able to further reduce the relaxation observed after NOS inhibitors. 6. These results suggest that nitric oxide (NO) and a peptid...Continue Reading

References

Dec 1, 1992·Gastroenterology·M E Stark, J H Szurszewski
Dec 15, 1992·European Journal of Pharmacology·A CalignanoS Moncada
Apr 1, 1992·Journal of Autonomic Pharmacology·F MulèA Postorino
Dec 1, 1991·The Journal of Physiology·M E StarkJ H Szurszewski
Sep 17, 1991·European Journal of Pharmacology·K IrieT Nomoto
Nov 15, 1990·Biochemical and Biophysical Research Communications·F HataO Yagasaki

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Citations

May 25, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Rita BenkóLorand Barthó
Aug 12, 1998·Journal of the Autonomic Nervous System·J RodrigoJ A Pedrosa
Feb 14, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S R MartinsG Ballejo
Aug 2, 2006·Autonomic & Autacoid Pharmacology·A M HamrouniK J Broadley
Dec 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M J BruinsN E P Deutz

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