Nitric oxide maintains dilation of immature and mature collaterals in rat hindlimb

Journal of Vascular Research
J L UnthankM C Dalsing

Abstract

The role of nitric oxide (NO) in maintaining collateral dilation was investigated in rats with acute and chronic superficial femoral artery occlusion. Collateral function was evaluated from arterial pressure measurements proximal (mean arterial pressure, MAP) and distal (PD) to the occlusion under resting and hyperemic conditions. For resting and hyperemic conditions, respectively, PD increased with the duration of occlusion from 34 +/- 2.1 and 14 +/- 0.8 mm Hg acutely postocclusion to 37 +/- 2.8 and 19 +/- 3.6, 42 +/- 4.9 and 25 +/- 1.5, and 49 +/- 5.6 and 25 +/- 2.1 mm Hg at 1, 4, and 12 weeks. After NO synthase inhibition with N omega-nitro-L-arginine methyl ester (L-NAME), PD in control limbs increased but in occluded limbs decreased by 20 +/- 2.0 mm Hg (acute) and 18 +/- 2.1, 15 +/- 4.4, and 20 +/- 8.1 mm Hg at 1, 4, and 12 weeks postligation, respectively. The percent of MAP (%MAP) dissipated by large arteries and collateral vessels decreased during collateral development (from 71 +/- 1.7% acutely to 57 +/- 2.2% at 12 weeks postligation) and was increased approximately 20% by L-NAME at each time point. The rise in PD and decrease in %MAP dissipated by collaterals following chronic occlusion indicates that significant coll...Continue Reading

Citations

May 24, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Sunita SrivastavaH T Yang
Aug 13, 2004·Vascular and Endovascular Surgery·Joseph L UnthankMichael C Dalsing
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H T YangRonald L Terjung
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P G LloydR L Terjung
May 11, 2006·European Journal of Clinical Investigation·S GulecC Erol
May 23, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Shyamal C BirChristopher G Kevil
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H T YangR L Terjung
Oct 17, 2008·Coronary Artery Disease·Ali YildizOzcan Erel
Oct 17, 2008·Coronary Artery Disease·Sinan Altan KocamanAtiye Cengel
Oct 9, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pamela G LloydRonald L Terjung

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