PMID: 7544575Sep 1, 1995Paper

Nitric oxide-mediated inactivation of mammalian ferrochelatase in vivo and in vitro: possible involvement of the iron-sulphur cluster of the enzyme

The Biochemical Journal
T FurukawaS Taketani

Abstract

To investigate the role of the iron-sulphur cluster in mammalian ferrochelatases, the terminal enzyme of the haem biosynthetic pathway, we examined the interaction of nitric oxide (NO) and ferrochelatase. When macrophage cell line RAW 264.7 cells were treated with interferon-gamma and lipopolysaccharide NO synthesis in the cells was stimulated, and a decrease in ferrochelatase activity was observed, with no change in the amount of ferrochelatase. The addition of NG-monomethyl-L-arginine, a selective inhibitor of NO synthesis, reduced the effect of interferon-gamma and lipopolysaccharide, while the effect of NG-monomethyl-L-arginine was suppressed by the addition of L-arginine, a substrate of NO synthase. When purified recombinant human ferrochelatase was treated with 3-morpholinosydnonimine, a NO-generating compound, ferrochelatase activity decreased with disappearance of characteristic absorbance spectra of the iron-sulphur cluster. S-Nitroso-N-acetylpenicillamine also reduced the activity, in a dose-dependent manner. These results indicate that ferrochelatase activity can be modulated by NO synthesis probably through disruption of the iron-sulphur cluster. We propose that inactivation of ferrochelatase mediated by NO (or NO-d...Continue Reading

Citations

Nov 14, 2006·The Journal of Trauma·Yohan RobinsonAndreas Oberholzer
Apr 22, 2009·Molecular BioSystems·Valerie HowerSuzy V Torti
Jul 14, 2010·Bioscience, Biotechnology, and Biochemistry·Tuan Thanh ChauShigeru Taketani
Nov 8, 2018·British Journal of Pharmacology·Dennis J Stuehr, Mohammad Mahfuzul Haque
Nov 22, 2008·Antioxidants & Redox Signaling·F Wayne Outten, Elizabeth C Theil
May 1, 2001·Current Protocols in Toxicology·S Taketani
Mar 18, 2016·Antioxidants & Redox Signaling·Arnab Ghosh, Dennis Stuehr
Jul 21, 2000·European Journal of Biochemistry·S TaketaniY Nakahashi
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·D J Stuehr
Jan 16, 2004·Critical Care Medicine·Marion Scharte, Mitchell P Fink
Nov 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hani AtamnaBruce N Ames
Jul 3, 2008·The Journal of Biological Chemistry·Gregory A HunterGloria C Ferreira
Aug 20, 2011·Journal of Porphyrins and Phthalocyanines·Gregory A HunterGloria C Ferreira
Apr 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Dhara PatelMichael S Wolin
Dec 6, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher Trent BrewerTaosheng Chen
Feb 1, 2013·The Biochemical Journal·Marc R MikhaelPrem Ponka
May 5, 1999·Current Opinion in Chemical Biology·H Beinert, P J Kiley
May 13, 1999·Biochimica Et Biophysica Acta·R CammackM N Hughes
Mar 20, 1999·Kidney International. Supplement·G Weiss
Jul 20, 2002·Blood Reviews·Günter Weiss
Feb 14, 2002·Archives of Biochemistry and Biophysics·Hani AtamnaBruce N Ames
Jul 3, 2004·Ageing Research Reviews·Hani Atamna
Aug 18, 2004·Life Sciences·Yunying L LiuJoseph R Bloomer
Oct 19, 2011·Journal of Agricultural and Food Chemistry·Tuan Thanh ChauShigeru Taketani
Apr 9, 2010·Meat Science·Jun-ichi WakamatsuAkihito Hattori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.