Nitric Oxide-mediated Relaxation by High K in Human Gastric Longitudinal Smooth Muscle.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Young Chul KimSang Jin Lee

Abstract

This study was designed to elucidate high-K(+)induced response of circular and longitudinal smooth muscle from human gastric corpus using isometric contraction. Contraction from circular and longitudinal muscle stripes of gastric corpus greater curvature and lesser curvature were compared. Circular smooth muscle from corpus greater curvature showed high K(+) (50 mM)-induced tonic contraction. On the contrary, however, longitudinal smooth muscle strips showed high K(+) (50 mM)-induced sustained relaxation. To find out the reason for the discrepancy we tested several relaxation mechanisms. Protein kinase blockers like KT5720, PKA inhibitor, and KT5823, PKG inhibitor, did not affect high K(+)-induced relaxation. K(+) channel blockers like tetraethylammonium (TEA), apamin (APA), glibenclamide (Glib) and barium (Ba(2+)) also had no effect. However, N(G)-nitro-L-arginine (L-NNA) and 1H-(1,2,4) oxadiazolo (4,3-A) quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase (sGC) and 4-AP (4-aminopyridine), voltage-dependent K(+) channel (K(V)) blocker, inhibited high K(+)-induced relaxation, hence reversing to tonic contraction. High K(+)-induced relaxation was observed in gastric corpus of human stomach, but only in the longitud...Continue Reading

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Jun 23, 2009·Journal of Korean Medical Science·Young Chul KimSang Jin Lee
Dec 8, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Young Chul KimSang Jin Lee
Jan 8, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Young Chul KimHyo-Yung Yun
Dec 18, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyo-Yung YunSang Jin Lee

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Citations

Jan 29, 2013·Acta Odontologica Scandinavica·Dong-Hun HanJin-Bom Kim
Mar 19, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Fang-Fei LiuYuan Lin
Aug 16, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Seung Hwa HongSang Jin Lee
Nov 3, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Dae Hoon KimSang Jin Lee
Oct 30, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sang Eok LeeSang Jin Lee
Jun 26, 2020·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Sang Eok LeeHyo-Yung Yun
Nov 12, 2014·World Journal of Gastroenterology : WJG·Li-Xue ZhangQin Ma
Dec 22, 2020·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Yu-Ling SunJian Li

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